叶金星
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电话: 021-64251830
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传真: 021-64251830
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E-mail: yejx@ecust.edu.cn
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个人简介
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叶金星，博士，教授，博士生导师。1997年获中南工业大学（现中南大学）工学学士学位；2000年获广西大学理学硕士学位，从事计算化学研究（导师：龙翔云教授，胡皆汉研究员，程国宝研究员）；2004年获中国科学院大连化学物理研究所理学博士学位（导师：梁鑫淼研究员），从事有机合成化学研究。2004年11月至2006年10月先后在英国曼切斯特大学化学学院Darren J. Dixon教授实验室(现在牛津大学)和日本名古屋大学诺贝尔奖获得者Ryoji Noyori(野依良治）和Saito Susumu教授研究室从事博士后研究。2013年11月至2015年1月在加州大学伯克利分校Jeffrey Reimer和Jeffrey R. Long教授实验室做访问研究。目前已在Nature Commun.,J. Am. Chem. Soc., Angew. Chem. Int. Ed.,Chem. Commun., Org. Lett., Chem. Eur. J., Adv. Synth & Catal等杂志发表五十余篇论文和申请十余项专利（包括1项国际PCT专利，部分已授权）。2007年受聘于华东理工大学药学院。2008年入选上海市“浦江人才计划”，2013年入选教育部“新世纪优秀人才支持计划”，负责国家自然科学基金、教育部和上海市教委科研项目和Eli Lilly国际合作项目，主要从事连续流动合成，不对称催化，绿色有机合成和药物合成工作。
欢迎有兴趣的青年学生联系报考研究生！
招聘师资博士后
因研究工作需要，实验室现招聘师资博士后2名。真诚欢迎有志于科研的年轻学者加盟。
待遇：
薪资请参考校博后标准，另外，会结合工作情况给予基本绩效和奖励，年收入具有竞争力（25万起）。
应聘条件：
1. 对科学研究、教育事业有浓厚兴趣，为人诚实，工作勤奋，富有责任心和团队精神；
2. 申请人具有有机化学，药物化学或制药工程专业基础或工作背景，以第一作者发表过SCI论文；
3. 已取得或即将取得博士学位；
4. 有中试研究、实际生产经验者优先。
应聘材料：
1.个人简历（学习、工作经历，研究背景，发表论文等详细材料）；
2.获奖证书复印件等其他相关证明材料。
欢迎联系：
地址：上海市徐汇区梅陇路130号华东理工大学
联系人：叶老师
Email: yejx@ecust.edu.cn
研究方向
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1. 连续流动合成：连续合成工艺；快速合成；新技术的发展。
2. 手性合成：手性胺催化；不对称金属催化；催化不对称反应中的位置和非对映选择性调控的新方法；光催化和电催化不对称合成。
3. 药物化学：活性药物的合成与构效关系研究。
4. 合成工艺：手性药物、天然药物、香料等的合成新技术。
欢迎重视人才培养和医药研发的企业与我们合作，欢迎有志青年学生加盟从事上述方向的研究和开发工作！
获奖成果
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1. 2004年 The Royal Society Postdoctoral Fellowship
3. 2011年 “天鼎-东岳”研究生奖教金一等奖
4. 2012年 Thieme Chemistry Journal Award
代表性论著
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64. Shupeng Dong, Guibing Wu, Xiaoqian Yuan, Chuncheng Zou, Jinxing Ye, Visible-light photoredox catalyzed hydroacylation of electron-deficient alkenes: carboxylic anhydride as an acyl radical source, Org. Chem. Front., 2017, 4, 2230-2234.
63. Xiaoqian Yuan, Shupeng Dong, Zhen Liu, Guibing Wu, Chuncheng Zou, Jinxing Ye, Enantioselective Michael Addition of Photogenerated o-Quinodimethanes to Enones Catalyzed by Chiral Amino Acid Esters, Org. Lett., 2017, 19, 2322-2325.
62. Kaihe Zou, Xin-Yan Wu, Jinxing Ye, Brønsted acid-catalyzed aza-Mannich reaction of N-Boc aminals: access to multifunctional rhodanine/hydantoin derivatives, Res. Chem. Intermediat., 2017, 43, 4503-4516.
61. Mercedes K. Taylor, Tomče Runčevski, Julia Oktawiec, Miguel I. Gonzalez, Rebecca L. Siegelman, Jarad A. Mason, Jinxing Ye, Craig M. Brown, and Jeffrey R. Long, Tuning the Adsorption-Induced Phase Change in the Flexible Metal–Organic Framework Co(bdp), J. Am. Chem. Soc., 2016, 138, 15019-15026.
60. Chuncheng Zou, Chuikun Zeng, Zhen Liu, Min Lu, Xiaohua Sun, Jinxing Ye, gamma'-Selective Functionalization of Cyclic Enones: Construction of a Chiral Quaternary Carbon Center by [4+2] Cycloaddition/Retro-Mannich Reaction with 3-Substituted Maleimides, Angew. Chem. Int. Ed., 2016, 55, 14255-14259.
59. Song Zhang, Junzhu Lu, Jinxing Ye, Wei-liang Duan, Asymmetric C-H Arylation for the Synthesis of Planar Chiral Ferrocenes: Controlling Enantioselectivity Using Chiral Phosphoric Acids, Chin. J. Org. Chem., 2016, 36, 752-759.
58. Xiaoqian Yuan, Xinxin Wu, Shupeng Dong, Guibing Wu, Jinxing Ye, Bronsted Acid Cocatalysis in Photocatalytic Intramolecular Coupling of Tertiary Amines: Efficient Synthesis of 2-Arylindols, Org. Biomol. Chem., 2016, 14, 7447-7450.
57. Jie Fei, Qingqing Qian, Xiaohua Sun, Xiaodong Gu, Chuncheng Zou, and Jinxing Ye, Organocatalytic Enantioselective Formal [4+2] Cycloaddition of Enones with Cyclic N-Sulfonylimines and Methylene Chromene for Chiral Spirocyclic Compounds, Org. Lett.,2015, 17, 5296-5299.
56. Yuan Wei, Zunwu Liu, Xinxin Wu, Jie Fei, Xiaoqian Yuan, Jinxing Ye, Remote Construction of Chiral Vicinal Tertiary and Quaternary Centers by Catalytic Asymmetric 1,6-Conjugate Addition of Prochiral Carbon nucleophiles to Cyclic Dienones, Chem. Eur. J.,2015, 21, 18921-18924.
55. Kaihe Zou, Jinxing Ye, Xin-Yan Wu, Acid-catalyzed Efficient Friedel–Crafts Reaction of Indoles with N-Boc Aminals, Tetrahedron, 2015, 71, 7869-7873.
54. Kaihe Zou, Jinxing Ye, Xin-Yan Wu, An Efficient Synthesis of Styrenyl Enamides from 4-Aryl-2-Oxazolidinones in the Presence of Strong Base, Tetrahedron Letters, 2015, 56, 5517-5520.
53. Xiaodong Gu, Tingting Guo, Yuanyuan Dai, Allegra Franchino, Jie Fei, Chuncheng Zou, Darren J. Dixon and Jinxing Ye, Direct Catalytic Asymmetric Doubly Vinylogous Michael Addition of α,β-Unsaturated γ-Butyrolactams to Dienones, Angew. Chem. Int. Ed., 2015, 54, 10249–10253.
52. Fei Wang, Na Zhu, Pinhong Chen, Jinxing Ye, and Guosheng Liu, Copper-Catalyzed Trifluoromethylazidation of Alkynes: Efficient Access to CF3-Substituted Azirines and Aziridines, Angew. Chem. Int. Ed., 2015, 54, 9356–9360.
51. Xinxin Wu, Chunna Meng, Xiaoqian Yuan, Xiaotong Jia, Xuhong Qian and Jinxing Ye, Transition-Metal-Free Visible-Light Photoredox Catalysis at Room-Temperature for Decarboxylative Fluorination of Aliphatic Carboxylic Acids by Organic Dyes, Chem. Commun., 2015, 51, 11864–11867.
50. Na Zhu, Fei Wang, Pinhong Chen, Jinxing Ye, and Guosheng Liu, Copper-Catalyzed Intermolecular Trifluoromethylazidation and Trifluoromethylthiocyanation of Allenes: Efficient Access to CF3-Containing Allyl Azides and Thiocyanates, Org. Lett., 2015, 17, 3580–3583.
49. Yuan Wei, Shigang Wen, Zunwu Liu, Xinxin Wu, Bubing Zeng, and Jinxing Ye, Diastereodivergent Catalytic Asymmetric Michael Addition of 2-Oxindoles to α,β-Unsaturated Ketones by Chiral Diamine Catalysts, Org. Lett., 2015, 17, 2732–2735.
48. Haoxiang Hu, Chunna Meng, Yun Dong, Xin Li, and Jinxing Ye, Catalytic Asymmetric Formal Aza-Diels–Alder Reactions of α,β-Unsaturated Ketones and 3H-Indoles, ACS Catal., 2015, 5, 3700–3703.
47. Xiaodong Gu, Yuanyuan Dai, Tingting Guo, Allegra Franchino, Darren J. Dixon, and Jinxing Ye, A General, Scalable, Organocatalytic Nitro-Michael Addition to Enones: Enantioselective Access to All-Carbon Quaternary Stereocenters, Org. Lett., 2015, 17, 1505-1508.
46. Xin Li, Min Lu,Yun Dong, Wenbin Wu, Qingqing Qian, Jinxing Ye & Darren J Dixon, Diastereodivergent Organocatalytic Asymmetric Vinylogous Michael Reactions, Nature Communications, 2014, 5, 4479.
45. Jiabin Xu, Xin Mu, Pinhong Chen, Jinxing Ye, and Guosheng Liu, Copper-Catalyzed Trifluoromethylthiolation of Aryl Halides with Diverse Directing Groups, Org. Lett., 2014, 16, 3942–3945.
44. Junzhu Lu, Jinxing Ye, Wei-Liang Duan, Palladium-Catalyzed Asymmetric 1,6-Addition of Diarylphosphines to alpha, beta, gamma, delta-Unsaturated Sulfonic Esters: Controlling Regioselectivity by Rational Selection of Electron-Withdrawing Groups, Chem. Commun., 2014, 50, 698-700.
43. Junzhu Lu, Jinxing Ye, Wei-Liang Duan, Palladium-Catalyzed Asymmetric Addition of Diarylphosphines to alpha,beta-Unsaturated Sulfonic Esters for the Synthesis of Chiral Phosphine Sulfonate Compounds, Org. Lett., 2013, 15, 5016-5019.
42. Wenbin Wu, Xiaoqian Yuan, Juan Hu, Xinxin Wu, Yuan Wei, Zunwu Liu, Junzhu Lu, Jinxing Ye, Catalytic Asymmetric Construction of Chiral Hydropyridazines via Conjugate Addition of N-Monosubstituted Hydrazones to Enones, Org. Lett., 2013, 15, 4524–4527.
41. Huicai Huang, Wenbin Wu, Kailong Zhu, Juan Hu, Jinxing Ye, Highly Diastereo- and Enantioselective Cross-Cascade Reactions of Different Enones, Chem. Eur. J., 2013, 19, 3838-3841.
40. Kailong Zhu, Huicai Huang, Wenbin Wu, Yuan Wei, Jinxing Ye, Aminocatalyzed Asymmetric Diels–Alder Reaction of 2,4-Dienals and Rhodanine/Hydantoin Derivatives, Chem. Commun., 2013, 49, 2157-2159.
39. Wenbin Wu, Xin Li, Huicai Huang, Xiaoqian Yuan, Junzhu Lu, Kailong Zhu, Jinxing Ye, Asymmetric Intramolecular Oxa-Michael Reactions of Cyclohexadienones Catalyzed by a Primary Amine Salt, Angew. Chem. Int. Ed., 2013, 52, 1743–1747.
38. Wenbin Wu, Huicai Huang, Xiaoqian Yuan, Kailong Zhu, Jinxing Ye, Asymmetric Construction of Spirocyclohexanonerhodanines Catalyzed by Simple Diamine Derived from Chiral tert-Leucine, Chem. Commun., 2012, 48, 9180–9182.
37. Feng Yu, Haoxiang Hu, Xiaodong Gu, Jinxing Ye, Asymmetric Michael Addition of Substituted Rhodanines to α,β-Unsaturated Ketones Catalyzed by Bulky Primary Amines, Org. Lett.,2012, 14, 2038–2041.
36. Huicai Huang, Kailong Zhu, Wenbin Wu, Zhichao Jin, Jinxing Ye, Highly Diastereoselective and Enantioselective Michael Addition of 5H-Oxazol-4-ones to α, β-Unsaturated Ketones Catalyzed by a New Bifunctional Organocatalyst with Broad Substrate Scope and Applicability, Chem. Commun., 2012, 48, 461-463.
35. Xiaoyan Luo, Zhiqiang Zhou, Xin Li, Xinmiao Liang, Jinxing Ye, Enantioselective Organocatalytic Phospha-Michael Reaction of α,β-Unsaturated Aldehydes, RSC Advances, 2011, 1, 698–705.
34. Wenjun Li, Xin Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye, Highly Diastereo- and Enantioselective One-Pot Michael-Aldol Reactions of α, β-Unsaturated Aldehydes with Imidazole Derivatives, Chem. Commun., 2011, 47, 8325–8327.
33. Juanjuan Yang, Huicai Huang, Zhichao Jin, Wenbin Wu, Jinxing Ye, Diastereoselective Synthesis of Bicyclo[2.2.2]octan-2-one Derivatives through An Unexpected Organocatalytic Tandem Michael-Michael Reaction, Synthesis, 2011, 1984-1987.
32. Wenjun Li, Xin Li, Tingting Ye, Wenbin Wu, Xinmiao Liang, Jinxing Ye, Asymmetric Organocatalytic Michael/α-Alkylation Reaction of α, β-Unsaturated Aldehyde with Chloroacetophenone, Tetrahedron Lett., 2011, 52, 2715-2718.
31. Xiaoyan Luo, Zhiqiang Zhou, Feng Yu, Xin Li, Xinmiao Liang, and Jinxing Ye, Asymmetric Vinylogous Michael Reaction of α, β-Unsaturated Aldehyde with Buteno-4-lactone, Chem., Lett.,2011, 40, 518-520.
30. Huicai Huang, Zhichao Jin, Kailong Zhu, Xinmiao Liang, Jinxing Ye, Highly Diastereo- and Enantioselective Synthesis of 5-Substituted 3-Pyrrolidin-2-Ones through A Direct Vinylogous Michael Addition under Multifunctional Catalysis, Angew. Chem. Int. Ed.,2011, 50, 3232-3235.
29. Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye, Asymmetric Direct Michael Addition of Acetophenone to α, β-Unsaturated Aldehyde, Synthesis, 2011, 1085-1091.
28. Wenjun Li, Wenbin Wu, Feng Yu, Huicai Huang, Xinmiao Liang, Jinxing Ye, Catalytic Asymmetric Michael Addition with Curcumin Derivative, Org. Biomol. Chem.,2011, 9, 2505-2511.
27. Zhichao Jin, Xiao Wang, Huicai Huang, Xinmiao Liang, Jinxing Ye, Diastereo- and Enantioselective Synthesis of Oxazine and Oxazolidine Derivatives with Chiral Quaternary Carbon Center under Multifunctional Catalysis, Org. Lett.,2011, 13, 564-567.
26. Zhichao Jin, Huicai Huang, Wenjun Li, Xiaoyan Luo, Xinmiao Liang, Jinxing Ye, Enantioselective Organocatalytic Synthesis of Oxazolidine Derivatives through A One-pot Cascade Reaction, Adv. Synth. Catal.,2011, 353, 343-348.
25. Zhichao Jin, Feng Yu, Xiao Wang, Huicai Huang, Xiaoyan Luo, Xinmiao Liang, Jinxing Ye, A One-pot Asymmetric Organocatalytic Tandem Reaction for the Synthesis of Oxazine Derivatives, Org. Biomol. Chem.,2011, 9, 1809-1816.
24. Xiaoyan Luo, Zhichao Jin, Pengfei Li, Jiabin Gao, Weimin Yue, Xinmiao Liang, Jinxing Ye, Catalytic Asymmetric Michael Addition of α, β-Unsaturated Aldehydes with Ni(II) Complexes of the Schiff Base of Glycine, Org. Biomol. Chem.,2011, 9 (3), 793-801.
23. Xiaomin Sun, Feng Yu, Tingting Ye, Xinmiao Liang, Jinxing Ye, Catalytic Asymmetric Michael Reaction of α, β-Unsaturated Ketones with Sulfonyl Containing Nucleophiles: Chiral Synthesis of R-Muscone and S-Celery Ketone, Chem. Eur. J., 2011, 17, 430-434.
22. Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, Jinxing Ye, Enantioselective Michael Reaction of α-Alkyl-β-Keto Esters and Enones under Multifunctional Catalysis, Org. Lett.,2010, 12, 5218-5221.
21. Feng Yu, Zhichao Jin, Huicai Huang, Tingting Ye, Xinmiao Liang, Jinxing Ye, A Highly Efficient Asymmetric Michael Addition of α, α-Disubstituted Aldehydes to Maleimides Catalyzed by Primary Amine Thiourea Salt, Org. Biomol. Chem.,2010, 8, 4767-4774.
20. Yufeng Zhou, Xin Li, Wenjun Li, Chunlin Wu, Xinmiao Liang, Jinxing Ye, Asymmetric Organocatalytic Michael Addition of α, β-Unsaturated Ketone with 1,2,4-Triazole, Synlett, 2010, (15) , 2357-2360.
19. Huicai Huang, Feng Yu, Zhichao Jin, Wenjun Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye, Asymmetric Vinylogous Michael Reaction of α, β-Unsaturated Ketones with γ-Butenolide under Multifunctional Catalysis, Chem. Commun., 2010, 46, 5957-5959.
18. Feng Yu, Xiaomin Sun, Zhichao Jin, Shigang Wen, Xinmiao Liang, Jinxing Ye, Enantioselective Michael Addition of Ketones to Maleimides Catalyzed by Bifunctional Monosulfonyl DPEN Salt, Chem. Commun., 2010, 46, 4589-4591.
17. Shigang Wen, Pengfei Li, Haibo Wu, Feng Yu, Xinmiao Liang, Jinxing Ye, Enantioselective Organocatalytic Phospha-Michael Reaction of α, β-Unsaturated Ketones, Chem. Commun., 2010, 46, 4806-4808.
16. Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang, Jinxing Ye, Asymmetric Organocatalytic Michael Addition of Anthrone to Enone, Org. Biomol. Chem., 2010, 8, 3244-3250.
15. Pengfei Li, Shigang Wen, Feng Yu, Qiaoxia Liu, Wenjun Li, Yongcan Wang, Xinmiao Liang, Jinxing Ye, Enantioselective Organocatalytic Michael Addition of Malonates to α, β-Unsaturated Ketones, Org. Lett.,2009, 3, 753-756.
14. Pengfei Li, Yongcan Wang, Xinmiao Liang, Jinxing Ye, Asymmetric Multifunctional Organocatalytic Michael Addition of Nitroalkanes to α, β-Unsaturated Ketones, Chem. Commun., 2008, 3302-3304.
13. Yongcan Wang, Pengfei Li, Xinmiao Liang, Jinxing Ye, Base - Base Bifunctional Catalysis: A Practical Strategy for Asymmetric Michael Addition of Malonates to α, β-Unsaturated Aldehydes, Adv. Synth. Catal., 2008, 350, 1383-1389.
12. Yongcan Wang, Pengfei Li, Xinmiao Liang, Tony Y. Zhang, Jinxing Ye, An Efficient Enantioselective Method for Asymmetric Michael Addition of Nitroalkanes to α, β-Unsaturated Aldehydes, Chem. Commun., 2008, 1232-1234.
11. Yongping Zhang, Zhimou Guo, Jinxing Ye, Qing Xu, Xinmiao Liang, Aiwen Lei, Preparation of novel β-cyclodextrin chiral stationary phase based on click chemistry, J. Chromatography A,2008, 1191, 188-192.
10. Yongcan Wang, Jinxing Ye, Xinmiao Liang, Convenient Preparation of Chiral α, β-Epoxyketones via Claisen-Schmidt Condensation-Epoxidation Sequence, Adv. Synth. Catal.,2007, 349, 1033-1036.
9. A. L. Tillman, Jinxing Ye, D. J. Dixon, Direct Enantio- and Diastereoselective Mannich Reactions of Malonate and beta-Keto Esters with N-Boc- and N-Cbz-Aldimines Catalysed by a Bifunctional Cinchonine Derivative, Chem. Commun.,2006, 1191-1193.
8. Jinxing Ye, Darren J. Dixon, Peter S. Hynes, Highly Enantioselective Michael Addition of Malonate Esters to Nitro Olefins Using a Cinchonine-derived Bifunctional Organic Catalyst, Chem. Commun.,2005, 4481-4483.
7. Feifang Zhang, Jinxing Ye, Qing Zhang, Jiping Chen, Xinmiao Liang, Enantioseparation of Ranolazine using Shiseido Chiral CD-Ph Column by RP-HPLC, Chin. J. Anal. Lab. (Chinese),2005, 24(7), 48-50.
6. Yongcan Wang, Jinxing Ye, Xinmiao Liang, Research on the Epoxidation of Enone under Micellar Condition, Chin. J. Org. Chem. (Chinese),2005, 25(8), 969-971.
5. Jinxing Ye, Feifang Zhang, Qing Zhang, Jiping Chen, Xinmiao Liang, Chiral Separation of β-Blocking Agents by RP-HPLC, J. Instru. Anal. (Chinese),2004, 23, 80-82.
4. Jinxing Ye, Yongcan Wang, Jiping Chen, Xinmiao Liang, Trichloroisocyanuric Acid: A Convenient Oxidation Reagent for Phase-Transfer Catalytic Epoxidation of Enones under Non-Aqueous Conditions, Adv. Synth. Catal.,2004, 346, 691-696.
3. Jinxing Ye, Yongcan Wang, Renhua Liu, Guofu Zhang, Qing Zhang, Jiping Chen, Xinmiao Liang, A Highly Enantioselective Phase-Transfer Catalyzed Epoxidation of Enones with a Mild Oxidant of trichloroisocyanuric Acid, Chem. Commun., 2003, 2714–2715.
2. Jiehan Hu, Jinxing Ye, Guobao Cheng, Xiangyun Long, Quantum chemistry Ab Initio Calculation of Vibration Spectrum of β-Elemene, Spectrosc. Spect. Anal. (Chinese), 2001, 21, 163-168.
1. Jinxing Ye, Guobao Cheng, Jiehan Hu, Study on Computational Chemistry of Elemene and Its Derivatives: Ι. Theoretical Calculation of 13C NMR Chemical Shifts of β-Elemene, Chin. J. Mag. Reson. (Chinese), 2000, 17, 115-120.