程家高



程家高  教授、博导

（E-mail: jgcheng@ecust.edu.cn）

   

 

个人简介

 

程家高：博士、教授、博导，1978年生于山东。2000年7月毕业于山东曲阜师范大学化学系，获理学学士学位；2005年7月毕业于中国科学院上海药物研究所，获有机化学药物设计方向博士学位，导师：陈凯先院士、蒋华良院士；2007年9月华东理工大学药学院博士后出站后留校工作，2009年晋升副教授，2016年晋升教授。


主要研究方向：1）作用于烟碱乙酰胆碱受体、GABA受体等重要医药、农药靶标的活性分子设计、合成及构效关系研究；2）重磅杀虫剂品种的作用机制、生态毒性及抗性机制研究。
 

在JAFC; Chem. Biol. Drug. Des.; QSAR Comb. Sci.; J. Org. Chem.; Chem. Phys. Lett.; Bioorg. Med. Chem. Lett.; J. Phys. Org. Chem；JACS等国际重要学术期刊上发表外文SCI论文六十余篇。作为课题负责人，共承担国家自然科学基金3项、国家重点研发计划子课题1项、教育部博士点基金等省部级科研基金3项、中央高校基本科研业务费3项；作为骨干研究人员，承担国家973、863、科技支撑课题等国家重点课题多项。


 

代表性科研项目

 

[1]  国家重点研发计划项目课题，农药对靶沉积的界面作用过程与传输机制，编号：2017YFD0200306，2017.07-2020.12；课题骨干兼子课题负责人（雾滴对靶沉积的界面效应与关系模型，编号：2017YFD020030601）。


[2]  国家自然科学基金，基于昆虫和鱼类GABA受体差异研究的低鱼毒杀虫剂合理设计，编号：21572059，2016.01-2019.12，负责人。


[3]  国家自然科学基金，分子聚集态及分子间相互作用对化合物生物活性的影响研究，编号：21172070，2012.01-2015.12，负责人。


[4]  国家自然科学基金，计算机辅助新烟碱－烟碱乙酰胆碱受体的作用模式及新烟碱类杀虫剂的设计研究，编号：20802018，2009.01-2011.12，负责人。


[5]  中央高校基本科研业务费基金，绿色生态杀虫剂的分子设计，编号：222201718004，2017.03-2017.12，负责人。



代表性研究论文

  

  1. Chengchun Zhu#, Guanglong Li#, Keya Xiao, Xusheng Shao, Jiagao Cheng*, Zhong Li. Water bridges are essential to neonicotinoids: Insights from synthesis, bioassay and molecular modelling studies. Chin. Chem. Lett., 2019, 30(1), 255-258

  2. Bo Zhang#, Lei Zhang#, Lujue He#, Xiaodong Yang, Yali Shi, Shaowei Liao, Shan Yang, Jiagao Cheng*, Tianrui Ren*. Interactions of fipronil in fish and insects: experimental and molecular modeling studies. J. Agric. Food Chem. 2018, 66(23), 5756–5761. (一区，封面文章)

  3. Wei Li#, Jiuhui Li#, Hongfeng Shen, Jiagao Cheng*, Zhong Li, Xiaoyong Xu*. Synthesis, nematicidal activity and docking study of novel chromone derivatives containing substituted pyrazole. Chin. Chem. Lett., 2018, 29(6), 911-914.

  4. Xiaoqing Meng, Chengchun Zhu, Yue Feng, Weihua Li, Xusheng Shao, Zhiping Xu, Jiagao Cheng*, Zhong Li. “Computational Insights into the Different Resistance Mechanism of Imidacloprid versus Dinotefuran in Bemisia tabaci.” J. Agric. Food Chem. 2016, 64, 1231-1238. (一区)

  5. Dan-Ping Jiang, Cheng-Chun Zhu, Xu-Sheng Shao, Jia-Gao Cheng*, Zhong Li. “Bioactive conformation analysis of anthranilic diamide insecticides: DFT-based potential energy surface scanning and 3D-QSAR investigations.” Chin. Chem. Lett., 2015, 26, 662-666

  6. Nan Zheng, Jiagao Cheng*, Wei Zhang, Weihua Li, Xusheng Shao, Zhiping Xu,Xiaoyong Xu, Zhong Li*. “Binding Difference of Fipronil with GABAARs in Fruitfly and Zebrafish: Insights from Homology Modeling, Docking and Molecular Dynamics Simulation Studies” J. Agric. Food. Chem. 2014, 62, 10646-10653. (一区)

  7. Zheng Wang, Jinjin Ye, Rui Wu, Yang-Zi Liu, John S Fossey, Jiagao Cheng*, Wei-Ping Deng*. “Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols.” Catal. Sci. Technol. 2014, 4, 1909-1913. (二区，封面文章)

  8. Shuang Xia, Yue Feng, Jiagao Cheng*, Haibin Luo, Zhong Li*, Zhengming Li. “QAAR exploration on pesticides with high solubility: An investigation on sulfonylurea herbicide dimers formed through π-π stacking interactions.” Chin. Chem. Lett., 2014, 25(7), 973-977

  9. Shuang Xia, Jiagao Cheng*, Yue Feng, Xusheng Shao, Haibin Luo, Zhiping Xu, Xiaoyong Xu and Zhong Li*. “Computational Investigations about the Effects of Hetero-molecular Aggregation on Bioactivities: a Case of Neonicotinoids and Water.” Chin. J. Chem., 2014, 32(4), 324-334.

  10. Ying Yang, Wei Zhang, Jiagao Cheng*, Yun Tang, Yanqing Peng, Zhong Li*. “Pharmacophore, 3D-QSAR and Bayesian Model Analysis for Ligands Binding at the Benzodiazepine Site of GABAA Receptors: the Key Roles of Amino Group and Hydrophobic Sites.”Chem. Biol. Drug. Des.2013, 81, 583-590. (封面文章)

  11. Wei Zhang, Shuang Xia, Jinjin Ye, Yun Tang, Zhong Li*, Weiping Zhu, Jiagao Cheng*. “Structural Features of GABAA Receptor Antagonists: Pharmacophore Modeling and 3D-QSAR Studies.”Med. Chem. Res. 2013, 22, 5961-5972.

  12. Hou-ling Dai, Li-xin Gao, Ying Yang, Jing-ya Li, Jiagao Cheng*, Jia Li*, Ren Wen, Yan-qing Peng, Jian-bin Zheng*. “Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.” Bioorgan. Med. Chem. Lett. 2012, 22, 7440-7443.

  13. Wenwen Zhang, Yefeng Fan, Tao Yu, Zhiping Xu, Xiaoyong Xu*, Jiagao Cheng*, Zhong Li. “Synthesis, Insecticidal Assay and Molecular Docking Study of Novel Neonicotinoids N-Oxide Analogues. ” Chin. J. Chem., 2012, 30(2), 357-361.

  14. Tingting Cao, Yipei Ma,Xiuhua Yan, Jiagao Cheng*, Youhua Luo, Liming He, Weiliang Zhu*. “Is Free Cyclooctatetraene Dianion an Aromatic System? A Quantum Chemistry Study”, Chin. J. Chem. 2009, 27(10）, 1914-1918

  15. Lingyan He#,Jiagao Cheng#, Tao Wang, Caimei Li, Zhen Gong, Hong Liu, Bu-Bing Zeng, Hualiang Jiang, Weiliang Zhu. Cation-π complexes formed between cyclooctantetraene and alkaline earth metals: predicted and recorded NMR features, Chem. Phys. Lett. 2008, 462, 45-58. (#并列一作）

  16. Jiagao Cheng, WeiLiang Zhu, YanLi Wang, XiuHua Yan, Zhong Li, Yun Tang, HuaLiang Jiang*. The Open-Close Mechanism of M2 Channel Protein in Influenza A Virus: A Computational Study on the Hydrogen Bonds and Cation-pi interactions among His37 and Trp41, Sci. China Ser. B-Chem, 2008, 51(8), 768-775.

  17. Jiagao Cheng, XiaoMin Luo, XiuHua Yan, Zhong Li, Yun Tang, HuaLiang Jiang. WeiLiang Zhu,Research Progress in Cation-pi interactions, Sci. China Ser. B-Chem, 2008, 51(8), 709-717.

  18. Jiagao Cheng, Zhen Gong, Weiliang Zhu, Yun Tang, Weihua Li, Zhong Li, Hualiang Jiang. “Cation sitting in aromatic cages: ab initio computational studies on tetramethylammonium–(benzene)n (n=3–4) complexes”J. Phys. Org. Chem., 2007, 20, 448-457

  19. Jiagao Cheng, Weiliang Zhu, Yun Tang, Yufang Xu, Zhong Li, Kaixian Chen, Hualiang Jiang. “Effect of cation-π interaction on NMR: A theoretical investigation on complexes of Li+, Na+, Be2+, and Mg2+ with aromatics.” Chem. Phys. Lett. 2006, 422, 455-460.

  20. Jiagao Cheng, Congmin Kang, Weiliang Zhu, Xiaomin Luo, Chum Mok Puah, Kaixian Chen, Jianhua Shen*, Hualiang Jiang*. “N-Methylformamide-Benzene Complex as a Prototypical Peptide N-H∙∙∙π Hydrogen-Bonded System: Density Functional Theory and MP2 Studies.” J. Org. Chem. 2003, 68(2), 7490-7495.
网页发布时间: 2019-06-18