赵玉政 教授 博士生导师
国家优秀青年科学基金获得者
电话/传真：021-64251287
E-mail: yuzhengzhao@ecust.edu.cn
通讯地址：上海市徐汇区梅陇路130号实验18楼733室；邮编：200237
【个人简介】：
赵玉政，教授，博士生导师，国家优秀青年科学基金获得者，中国科协首批“青年人才托举工程”优秀人才，上海青年科技英才，上海市青年拔尖人才, 上海市青少年科技创新“市长”奖获得者，中国细胞生物学学会细胞代谢专业委员会委员，中国细胞生物学学会衰老细胞生物学专业委员会委员，中国老年学和老年医学学会老年病学分会衰老基础医学专家委员会委员，中国抗癌协会肿瘤代谢专业委员会委员，中国研究型医院学会过敏医学专业委员会青年委员。2007年7月获山东大学理学学士学位，2012年6月获华东理工大学工学博士学位并留校任教，历任讲师、副教授、研究员，现为华东理工大学教授。迄今已在Nature Methods、Cell Metabolism(2篇)、Nature Protocols(2篇)等国际权威期刊发表SCI论文27篇，编写英文著作Methods in Enzymology1个章节。已申请15项中国发明专利（授权6项）和2项国际PCT专利（授权2项美国发明专利）。研究成果在国际上产生重要影响，相关技术已被全球来自哈佛大学、斯坦福大学、麻省理工学院、牛津大学、剑桥大学及中国科学院等300多个实验室跟踪应用，典型技术应用发表于Science。主持国家重点研发计划课题、国家自然科学基金优秀青年科学基金、重大研究计划培育项目、面上项目、中国科协“青年托举”、上海市青年拔尖人才计划等科研项目。
【研究方向】：
1、细胞代谢原位检测与成像技术开发
2、细胞代谢调控机制研究
3、衰老及相关疾病（肿瘤、糖尿病、肥胖、心脑血管疾病等）创新药物开发
【研究生招生】：
本实验室研究对象涉及基因、蛋白质、细菌、哺乳动物细胞、线虫、斑马鱼、果蝇和小鼠，研究领域涉及药学、药理学、细胞生物学、生物化学与分子生物学、合成生物学、光遗传学、化学遗传学、化学生物学等。我们热忱欢迎有志于从事细胞代谢及代谢性疾病候选药物开发方面研究的同学加盟本实验室。
【近几年主要论文】（*通讯作者）：
1. Zou, Y., Wang, A., Shi, M., Chen, X., Liu, R., Li, T., Zhang, C., Zhang, Z., Zhu, L., Ju, Z., Loscalzo, J., Yang, Y.*, Zhao, Y.*. Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors. Nature Protocols, 2018, 13(10), 2362-2386.
2. Tao, R., Shi, M., Zou, Y.,Cheng, D., Wang, Q., Liu, R.,Wang, A., Zhu, J., Deng, L., Hu, H.,Chen, X.,Du, J.,Zhu, W., Zhao, Y.*, Yang, Y.*. Multicoloured fluorescent indicators for live-cell and in vivo imaging of inorganic mercury dynamics. Free Radical Biology & Medicine, 2018, 121, 26-37.
3. Hu, H., Wang, A., Huang, L., Zou, Y., Gu, Y., Chen, X., Zhao, Y.*, Yang, Y.*. Monitoring cellular redox state under hypoxia using a fluorescent sensor based on eel fluorescent protein. Free Radical Biology & Medicine, 2018, 120, 255-265.
4. Zhao, Y.*, Zhang, Z., Zou, Y., Yang, Y.*. Visualization of nicotine adenine dinucleotide redox homeostasis with genetically encoded fluorescent sensors. Antioxidants & Redox Signaling, 2018, 28(3), 213-229.
5.Liu, X., Zhang, F., Zhang, Y., Li, X., Chen, C., Zhou, M., Yu. Z., Liu, Y., Zhao, Y., Hao, X., Tang, Y., Zhu, L., Liu, L., Xie, L., Gu, H., Shao, H., Xia, F., Yin, C., Tao, M., Xie, J., Zhang, C., Yang, Y., Sun, H., Chen, G., Zheng, J. PPM1K regulates hematopoiesis and leukemogenesis through CDC20-mediated ubiquitination of MEIS1 and p21. Cell Reports, 2018, 23, 1461-1475.
6. Chen, X., Tian, M., Sun, R., Zhang, M., Zhou, L., Jin, L., Chen, L., Zhou, W., Duan, K., Chen, Y., Gao, C., Cheng, Z., Wang, F., Zhang, J., Sun, Y., Yu, H., Zhao, Y., Yang, Y., Liu, W., Shi, Y., Xiong, Y., Guan, K., and Ye, D. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer, EMBO Reports, 2018, e45124.
7. Tao, R.#,Zhao, Y.#, Chu, H.#, Wang, A., Zhu, J., Chen, X., Zou, Y., Shi, M., Liu, R., Su, N., Du, J., Zhou, H., Zhu, L., Qian, X., Liu, H., Loscalzo, J., and Yang, Y. Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism. (#Co-first authors). Nature Methods, 2017, 14(7), 720-728.
8. Chang, M., Li, L., Hu, H., Hu, Q., Wang, A., Cao, X., Yu, X., Zhang, S.*,Zhao, Y.*,Chen, J., Yang, Y., Xu, J. Using Fractional Intensities of Time-resolved Fluorescence to Sensitively Quantify NADH/NAD+with Genetically Encoded Fluorescent Biosensors. Scientific Reports, 2017, 7(1), 4209.
9. Hu, H., Gu, Y., Xu, L., Zou, Y., Wang, A., Tao, R., Chen, X.,Zhao, Y.*,Yang, Y.*. A genetically encoded toolkit for tracking live-cell histidine dynamics in space and time. Scientific Reports, 2017, 7, 43479.
10. Fang, Y., Liu, Z., Chen, Z., Xu, X., Xiao, M., Yu, Y., Zhang, Y., Zhang, X., Du, Y., Jiang, C.,Zhao, Y.,Wang, Y., Fan, B., Terheyden-Keighley, D., Liu, Y., Shi, L., Hui, Y., Zhang, X., Zhang, B., Feng, H., Ma, L., Zhang, Q., Jin, G., Yang, Y., Xiang, B., Liu, L., Zhang, X. Smad5 acts as an intracellular pH messenger and maintains bioenergetic homoeostasis. Cell Research, 2017, 27, 1083-1099.
11. Zhao, Y., Wang, A., Zou, Y., Su, N., Loscalzo, J., and Yang, Y. In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD+/NADH redox state. Nature Protocols, 2016, 11(8), 1345-1359. (Cover Story)
12. Zhao, Y.*, Yang, Y.*. Real-time and high-throughput analysis of mitochondrial metabolic states in living cells using genetically encoded NAD+/NADH sensors. Free Radical Biology & Medicine, 2016, 100, 43-52.
13. Yang, K., Wang, M.,Zhao, Y., Sun, X., Yang, Y., Li, X., Zhou, A., Chu, H., Zhou, H., Xu, J., Wu, M., Yang, J., and Yi, J. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nature Communications, 2016, 7, 13599.
14. Zhao, Y., Hu, Q., Cheng, F., Su, N., Wang, A., Zou, Y., Hu, H., Chen, X., Zhou, H., Huang, X.,Yang, K., Zhu, Q., Wang, X., Yi, J., Zhu, L., Qian, X., Chen, L., Tang, Y., Loscalzo, J., and Yang, Y. SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents. Cell Metabolism, 2015, 21(5), 777-789.
15. Zhao, Y., and Yang, Y. Profiling metabolic states with genetically encoded fluorescent biosensors for NADH. Current Opinion in Biotechnology, 2015, 31, 86-92.
16. Yang, H., Zhou, L., Shi, Q.,Zhao, Y., Lin, H., Zhang, M., Zhao, S., Yang, Y., Ling, Z., Guan, K., Xiong, Y., and Ye, D. SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. EMBO Journal, 2015, 34, 1110-1125.
17. Wang, Y., Zhou, L.,Zhao, Y., Wang, S., Chen, L., Liu, L., Ling, Z., Hu, F., Sun, Y., Zhang, J., Yang, C., Yang, Y., Xiong, Y., Guan, K., and Ye, D. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO Journal, 2014, 33, 1304–1320.
18. Zhao, Y., Jin, J., Hu, Q., Zhou, H.M., Yi, J., Yu, Z., Xu, L., Wang, X., Yang, Y., and Loscalzo, J. Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metabolism, 2011, 14(4), 555-566.
【著作】：
1. Zhao, Y., Yang, Y., and Loscalzo, J.Real-Time Assessment of the Metabolic Profile of Living Cells with Genetically Encoded NADH Sensors. Methods in Enzymology, 2014, 542, 349-367. (ISBN：978-0-12-416618-9)