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姓 名:赵振江
职 称:副研究员
电 话:021-64253962
传 真:
email :zhjzhao@ecust.edu.c

人物详情

      博士,男,1963 年8 月出生,华东理工大学药学院副教授。现主要研究领域为药物化学、植物保护和有机合成。
      1986年-1990年在西北大学化学系获得硕士学位,2001年-2004年在华东理工大学获应用化学博士。2005年5月-2008年1月完成博后课题(上海交通大学-赞南药业)。1990年-2001年在中国乐凯胶片集团公司研究院照相有机物研究室主任,完成多项技术开发项目,熟悉产品研发和较大规模的化工产品生产研发。1999年-2000年在德国Merseburg技术大学做访问研究。2004.8-2010.4月在上海药企任研发部主任,主持一系列与国外公司合作的研发项目。2010.5至今在华东理工大学药学院任副教授,在上海市新药设计重点实验室李洪林教授课题组负责新药研发中结构优化设计和合成部分工作。获得一项国家自然科学基金面上项目(2014),参与多项国家重大专项和上海科委项目研究。
研究方向:药物化学、有机化学和植物保护,包括各种激酶抑制剂药物研发,绿色植物保护产品开发和有机合成方法学研究。

科研成果(论文和专利申请情况):
1.       Wei Zhou, Xiaofeng Liu, Zhengchao Tu, Xin Ku, Fang Bai, Zhenjiang Zhao, Ke Ding,, Honglin Li, Yufang Xu; Scaffold hopping via hybrid molecular 3D similarity, a successful paradigm for design and optimization of novel irreversible inhibitors targeting epidermal growth factor receptor (EGFR) tyrosine kinase T790M/L858R Mutant; J. Med. Chem. 2013(online).
2.       Minghao Xu, Junsheng Zhu, Yanyan Diao, Hongchang Zhou, Xiaoli Ren, Deheng Sun, Jin Huang, Zhenjiang Zhao, Lili Zhu,*, Honglin Li,*, Yufang Xu,*; Novel, Selective and Potent Inhibitors of Malaria Parasite Dihydroorotate Dehydrogenase; J. Med. Chem. 2013, 56, 7911−7924.
3.       Jun Yuan, Ye Zhong, Shiliang Li, Xue Zhao, Guoqin Luan, Zhenjiang Zhao, Jin Huang, Honglin Li, and Yufang Xu; Triazole and Benzotriazole Derivatives as Novel Inhibitors for p90 Ribosomal S6 Protein Kinase 2: Synthesis, Molecular Docking and SAR Analysis; Chin. J. Chem. 2013, 31, 1192-1198.
4.       Jun Yuan, Zhenjiang Zhao*, Weiping Zhu, Honglin Li, Xuhong Qian, Yufang Xu; New strategy for the synthesis of 2-phenylbenzimidazole derivatives with sodium perborate (SPB) as oxidant; Tetrahedron,69 (34), (2013) , 7026-7030. (通讯作者)
5.       Liyan Wang, Chunmei Yang , Weiqiang Lu, Li Liu, Rui Gao, Sha Liao, Zhenjiang Zhao, Lili Zhu, Yufang Xu, Honglin Li, Jin Huang, Weiping Zhu;Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening;Bioorganic & Medicinal Chemistry Letters 23 (2013) 3496–3499.
6.       Xiaojuan Yu, Xue Zhao, Lili Zhu, Chuanxin Zou, Xiaofeng Liu, Zhenjiang Zhao, Jin Huang* and Honglin Li*. Discovery of novel inhibitors for human farnesyltransferase (hFTase) via structure-based virtual screening. Med. Chem. Commun., 2013. 4:962-971.
7.       Rui Gao, Sha Liao, Chen Zhang, Weilong Zhu, Liyan Wang, Jin Huang, Zhenjiang Zhao, Honglin Li, Xuhong Qian, Yufang Xu. Structure-Activity Relationships and Optimization of Heterocyclic Substituted Benzene Sulfonamides as Novel Cabonic Anhydrase IX Inhibitors. European Journal of Medicinal Chemistry. 62 (2013), 597-604. (通讯作者)
8.       Ye Zhong, Mengzhu Xue, Weiqiang Lu, Jin Huang, Honglin Li, Xiaofeng Liu, Zhenjiang Zhao, Yufang Xu. Substituted Indolin-2-ones as p90 Ribosomal S6 Protein Kinase 2 (RSK2) Inhibitors: Molecular docking simulation and structure-activity relationship analysis.Bioorg. Med. Chem. (2013) 1724–1734.(通讯作者)
9.       Mengzhu Xue, Jun Yuan, Bin Wu, Xue Zhao, Xiaofeng Liu, Jin Huang, Zhenjiang Zhao, Honglin Li, Yufang Xu. Novel inhibitors for p90 ribosomal S6 protein kinase 2: design, synthesis and SAR. Journal of Chinese Pharmaceutical Sciences 21 (2012) 401–408. (通讯作者)
10.   Yanyan Diao, Weiqiang Lu, Huangtao Jin, Junsheng Zhu, Le Han, Minghao Xu, Rui Gao, Xu Shen, Zhenjiang Zhao, Xiaofeng Liu, Yufang Xu, Jin Huang, and Honglin Li. Discovery of Diverse Human Dihydroorotate Dehydrogenase Inhibitors as mmunosuppressive Agents by Structure-Based Virtual Screening. J. Med. Chem. 2012, 55, 8341−8349.
11.   Mengzhu Xue, Xianwen Cao, Ye Zhong, Dong Kuang, Xiaofeng Liu, Zhenjiang Zhao and Honglin Li. Insulin-like Growth Factor-1 Receptor (IGF-1R) Kinase Inhibitors in Cancer Therapy: Advances and Perspectives. Current Pharmaceutical Design,2012, 18, 2901-2913.
12.   Mengzhu Xue, Minghao Xu, Weiqiang Lu, Jin Huang, Honglin Li, Yufang Xu, Xiaofeng Liu, and Zhenjiang Zhao. Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 2013; 28(4): 747–752.(通讯作者)
13.   Qingshan Du, Weiping Zhu, Zhenjiang Zhao, Xuhong Qian, and Yufang Xu. Novel Benzo-1,2,3-thiadiazole-7-carboxylate Derivatives As Plant Activators and the Development of Their Agricultural Applications. J. Agric. Food Chem. 2012, 60, 346−353.(通讯作者)
14.   Fang Bai, Hongyan Liu, Linjiang Tong, Wei Zhou, Li Liu, Zhenjiang Zhao, Xiaofeng Liu, Hualiang Jiang, Xicheng Wang, Hua Xie, Honglin Li. Discovery of novel selective inhibitors for EGFR-T790M/L858R. Bioorganic & Medicinal Chemistry Letters 22 (2012) 1365–1370.
15.   Shiliang Li, Yi Zhou, Weiqiang Lu, Ye Zhong, Wenlong Song, Kangdong Liu, Jin Huang, Zhenjiang Zhao, Yufang Xu, Xiaofeng Liu, and Honglin Li. Identification of Inhibitors against p90 Ribosomal S6 Kinase 2 (RSK2) through Structure-Based Virtual Screening with the Inhibitor-Constrained Refined Homology Model. J. Chem. Inf. Model. 2011, 51, 2939–2947.
16.   Huameng Li, Aiguo Liu, Zhenjiang Zhao, Yufang Xu, Jiayuh Lin, David Jou, and Chenglong Li. Fragment-Based Drug Design and Drug Repositioning Using Multiple Ligand simultaneous Docking (MLSD): Identifying Celecoxib and Template Compounds as Novel Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3). J. Med. Chem. 2011, 54, 5592–5596.
17.   Weiqiang Lu, Xiaofeng Liu, Xianwen Cao, Mengzhu Xue, Kangdong Liu, Zhenjiang Zhao, Xu Shen, Hualiang Jiang, Yufang Xu, Jin Huang, and Honglin Li. SHAFTS: A Hybrid Approach for 3D Molecular Similarity Calculation. 2. Prospective Case Study in the Discovery of Diverse p90 Ribosomal S6 Protein Kinase 2 Inhibitors To Suppress Cell Migration. J. Med. Chem. 2011, 54, 3564–3574.
18.   Weiping Zhu, Zhenjiang Zhao, Yufang Xu,*Derivatives of Benzothiadiazole-7-Carboxylates: Synthesis and Biological Activity,Monatshefte fur Chemie,2008,39,1067-1071.
19.   Zhenjiang Zhao, Z-Y. James Zhan, Development of new ruthenium catalysts for metathesis reactions, Chemistry Today, Vol 24 nr 6, 2006.
20.   Qian Zhigang, Zhao Zhenjiang, etc. Novel Chemically Synthesized Salicylate Derivative as an Effective Elicitor for Inducing the Biosynthesis of Plant Secondary Metabolites, Biotechnol. Prog. 2006, 22, 331-333.
21.   Yufang Xu, Zhenjiang Zhao, Xuhong Qian, Zhigang Qian, Wenhong Tian, Jian-Jiang Zhong, Novel Unnatural Benzo-1,2,3-thiadiazole-7-carboxylate Elicitors of Taxoid Biosynthesis Journal of Agricultural Food Chemistry 54 (23): 8793-8798 2006.
22.   Zhi-Gang Qian, Zhen-Jiang Zhao, Yufang Xu, Xuhong Qian and Jian-Jiang Zhong Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites Applied Microbiology and Biotechnology, 71 (2): 164-167 2006.
23.   Wei wang, Zhenjiang Zhao, Yufang Xu, Xuhong Qian, Zhanjiang Zhong,Efficient Induction of Ginsenoside Biosynthesis and Alteration of Ginsenoside Heterogeneity in Cell Cultures of Panax notoginseng by Using Chemically Synthesized 2-Hydroxyethyl Jasmonate, Applied Microbiology & Biotechnology, 70 (3): 298-307 2006.
24.   Wei Wang, Zhenjiang Zhao, etc. Efficient elicatation of Ginsenoside biosynthesis in cell cultures of panax notoginseng by using self-chemically-synthesized Jasmonates, Biotechnology and Bioprocess Engineering 2005, 10: 162-165.
25.   Zhi-Gang Qian, Zhen-Jiang Zhao, Yufang Xu, Xuhong Qian, Jian-Jiang Zhong,A novel synthetic fluoro-containing jasmonate derivative acts as a chemical inducing signal for plant secondary metabolism, Applied Microbiology and Biotechnology, 2005,68,98-103.
26.   Zhi-Gang Qian, Zhen-Jiang Zhao, Yufang Xu, Xuhong Qian, Jian-Jiang Zhong, A Highly Efficient Strategy for Enhancing Taxoid Production by Repeated Elicitation with a Newly Synthesized Jasmonate in Fed-batch Cultivation of Taxus chinensis Cells, Biotechnology and Bioengineering90 (4): 516-521 2005.
27.   Zhi-Gang Qian, Zhen-Jiang Zhao, Wen-Hong Tian, Yufang Xu, Jian-Jiang Zhong, Xuhong Qian, Novel Synthetic Jasmonates as Highly Efficient Elicitors for Taxoid Production by Suspension Cultures of Taxus chinensis, Biotechnology Bioengineering.86(5), 2004, 594- 599.
28.   Zhi-Gang Qian, Zhen-Jiang Zhao, Yufang Xu,Xuhong Qian, Jian-Jiang Zhong, Novel Chemically Synthesized Hydroxyl-Containing Jasmonates as Powerful Inducing Signals for Plant Secondary Metabolism Biotechnology Bioengineering  86(7), 2004,809-816.
29.   Zhenjiang Zhao, Yufang Xu, Zhigang Qian, Wenhong Tian, Xuhong Qian, Jian-Jiang Zhong Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis Bioorganic and medicinal chemistry Letter, 14(18),2004, 4755-4758.
30.   Zhenjiang Zhao, Horst Hartmann. Synthesis of reactive condensation products of acetylaceton and their transformation into deeply colored metthine dyes. J. Prakt. Chem. 2000, 342(3), 249-255.
中国专利及国际专利申请:
1.         苯并噻二唑衍生物的诱导抗虫作用及其应用;国际专利申请PCT/CN2013/083646,2013年9月17日;李宝聚,钱旭红,石延霞,徐玉芳,朱维平,赵振江,杜青山,李鹏飞。
2.         哒嗪酮类化合物及其用途;国际专利申请PCT/CN2013/082984;2013年9月5日;徐玉芳、赵振江、李宝聚、钱旭红、朱维平、石延霞、韩景龙、李洪林、曹贤文、常康
3.         苯并[1,2,3]噻二唑-7-甲酸2,2,2-三氟乙酯在控制园艺作物虫害上的应用;申请日:2012年9月17日,申请号201210345773.4。李宝聚,钱旭红,石延霞,徐玉芳,朱维平,赵振江,杜青山,李鹏飞
4.         蝶啶酮衍生物及其作为EGFR、BLK、FLT3 抑制剂的应用,申请日:2013年4月2日,申请号为PCT/CN2013/073612。李洪林,徐玉芳,赵振江,周伟,刘晓峰,薛梦竹,张磊,张友利。
5.         一种杂环化合物及其用途,申请号:201310066432.8,20130301. 徐玉芳,赵振江,朱维平,李洪林,杜青山,李宝聚,石延霞,钱旭红。
6.         一种吡唑并嘧啶化合物及其用途,申请号:201310067016,20130301. 徐玉芳,赵振江,朱维平,李洪林,李鹏飞,李宝聚,石延霞,钱旭红。
7.         一种杂环化合物及其用途,申请号:201310046938.2,20130205. 徐玉芳,赵振江,朱维平,李洪林,韩景龙,李宝聚,石延霞,钱旭红。
8.         做为DHODH抑制剂的噻唑衍生物及其应用,PCT/CN2012/086816,2012.12.18,赵振江、黄瑾、李洪林、徐玉芳、朱丽丽、韩乐、许鸣豪、高瑞、刁妍妍、朱俊生、曹贤文、崔坤强。
9.         作为BLK、FLT3抑制剂的蝶啶酮衍生物及其应用,申请号:201210484897.0,2012年11月23日。李洪林 徐玉芳 赵振江 刘晓峰 周伟 白芳 薛梦竹 张磊 张友利。
10.     作为DHODH抑制剂的五元环二氢杂环酮类衍生物及应用,PCT/CN2012/084556,2012.11.14,李洪林、赵振江、黄瑾、徐玉芳、许鸣豪、刁妍妍、周洪昌,金黄涛、高瑞。
11.     徐玉芳;李洪林;赵振江;朱维平;李鹏飞;曹贤文;李宝聚;石延霞;钱旭红;苯并三氮唑类化合物及其用途;CN102827090A;2012.12.19。
12.     徐玉芳;赵振江;朱维平;徐峥;朱浩骏;李洪林;曹贤文;李宝聚;石延霞;钱旭红;N-芳基取代吡咯烷酮衍生物及其用途; CN102827056A;2012.12.19。
13.     钱旭红;朱维平;赵振江;杜青山;李宝聚;石延霞;徐玉芳;苯并[1,2,3]噻二唑-7-羧酸酯衍生物作为植物抗病激活剂的应用;CN102532058A;2012.07.04。
14.     钱旭红;赵振江;朱维平;李鹏飞;田振林;李宝聚;石延霞;徐玉芳;苯并[1,2,3]噻二唑含氟衍生物作为植物抗病激活剂的应用; CN102532059A;2012.07.04。
15.     世界专利公开:李洪林、赵振江、黄瑾、徐玉芳、许鸣豪、刁妍妍、周洪昌,金黄涛、高瑞;作为DHODH抑制剂的五员二氢杂环酮类衍生物及应用;WO 2013/075596A1,2013.05.30。
16.     世界专利公开:赵振江、黄瑾、李洪林、徐玉芳、朱丽丽、韩乐、许鸣豪、高瑞、刁妍妍、朱俊生、曹贤文、崔坤强;做为DHODH抑制剂的噻唑衍生物及其应用;WO 2013/056684A2,2013.04.25。
17.     李洪林;赵振江;黄瑾;徐玉芳;许鸣豪;刁妍妍;金黄涛;高瑞;二氢噻吩酮衍生物作为pfDHODH抑制剂的合成及应用;CN103127095A, 2013.06.05。
18.     赵振江;韩乐;许鸣豪;高瑞;黄瑾;刁妍妍;曹贤文;崔坤强;李洪林;徐玉芳;做为DHODH抑制剂的噻唑衍生物及其应用;CN103058949A, 2013.04.24。
19.     李洪林;黄瑾;曹贤文;赵振江;刘丽;卢伟强;崔坤强;许鸣豪;韩乐;徐玉芳;2-氨基苯并噻唑衍生物作为DHODH抑制剂的应用;CN103006645A, 2013.04.03。
20.     李洪林;刁妍妍;黄瑾;赵振江;崔坤强;卢伟强;许鸣豪;韩乐;徐玉芳;2,4-二取代噻唑类衍生物作为DHODH抑制剂的应用;CN103006653A, 2013.04.03。
21.     李洪林;徐玉芳;赵振江;黄瑾;高瑞;王立言;张辰;朱伟龙;杨春梅;苯磺酰胺类化合物及其用途;CN102702109A, 2012.10.03。
22.     徐玉芳;赵振江;黄瑾;朱维平;刘莉;王立言;杨春梅;朱伟龙;张辰;李洪林;磺酰胺类化合物及其用途;CN102702057A, 2012.10.03。
23.     李洪林;黄瑾;刘晓峰;赵振江;徐玉芳;卢伟强;刁妍妍;袁俊;宋雨薇;周伟;异吲哚-1,3二酮衍生物作为RSK2抑制剂的合成与应用;CN102688232A, 2012.09.26。
24.     李洪林;刘晓峰;黄瑾;赵振江;徐玉芳;卢伟强;许鸣豪;薛梦竹;高瑞;刘康栋;巴比妥酸衍生物作为RSK2抑制剂的合成与应用;CN102690238A, 2012.09.26。
25.     徐玉芳;赵振江;刘晓峰;黄瑾;李洪林;钟烨;卢伟强;曹贤文;刘康栋;苯并三氮唑衍生物做为RSK2抑制剂的合成及应用;CN102688233A, 2012.09.26。
26.     徐玉芳;黄瑾;赵振江;刘晓峰;李洪林;袁俊;朱俊生;王立言;偶氮类衍生物做为RSK2抑制剂的合成及应用;CN102688250A, 2012.09.26。
27.     李洪林;刘晓峰;赵振江;黄瑾;徐玉芳;李诗良;周艺;卢伟强;钟烨;旷东;宋文龙;吲哚酮衍生物作为RSK2抑制剂的合成与应用;CN102688234A, 2012.09.26。
28.     李洪林;赵振江;刘晓峰;黄瑾;徐玉芳;薛梦竹;袁俊;崔雷;曹贤文;吴彬;韩乐;苯并咪唑、噁唑和噻唑衍生物的合成及其应用;CN102617478A, 2012.08.01。
29.     钱旭红;朱维平;赵振江;杜青山;李宝聚;石延霞;徐玉芳;苯并[1,2,3]噻二唑-7-羧酸酯衍生物作为植物抗病激活剂的应用;CN102532058A;2012.07.04.
30.     钱旭红;赵振江;朱维平;李鹏飞;田振林;李宝聚;石延霞;徐玉芳;苯并[1,2,3]噻二唑含氟衍生物作为植物抗病激活剂的应用;CN102532059A;2012.07.04
31.     赵振江;朱维平;钱旭红;徐玉芳;周济;陈孟杰;制备苯并[d][1,2,3]噻二唑-7-甲酸三氟乙酯的改进方法;CN101973960A;2011.02.16
32.     钱旭红;徐玉芳;赵振江;黄军海;田文红;苯并噻二唑衍生物在植物抗病激活剂中的应用;CN1868277;2006.11.29
33.     钱旭红;钟建江;赵振江;钱志刚;徐玉芳;田文红;茉莉酮酸酯衍生物及其在植物细胞中的应用;CN1470494;2004.01.28
34.     钱旭红;钟建江;赵振江;钱志刚;徐玉芳;田文红;苯并噻二唑类化合物及其在植物细胞中的应用;CN1450057;2003.10.22

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