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姓 名:杨友
职 称:教授
电 话:021-64253851
传 真:
email :yangyou@ecust.edu.cn

人物详情

       2004年毕业于中国科学技术大学化学系,获理学学士学位。随后由中国科学技术大学和中国科学院上海有机化学研究所联合培养,于2010年获中国科学技术大学理学博士学位。2010年8月至2014年6月,在德国马克斯–普朗克胶体与界面研究所(Max-Planck Institute of Colloids and Interfaces)进行博士后研究。2014年9月任华东理工大学药学院副教授。2015年5月被聘为华东理工大学特聘教授。2015年9月晋升为教授,并被聘为博士生导师。目前主要从事糖化学和糖类药物的研究。先后获得中国科技大学优秀毕业生(2004),安徽省高等学校品学兼优毕业生(2004),德国马普学会奖学金(2010),欧盟重大项目高级工作合同(2012),第二批华东理工大学青年英才(2015),上海市浦江人才(2015),第十一批国家“千人计划”青年人才(2015)等荣誉称号和奖励。
       迄今已在J. Am. Chem. Soc.,Adv. Mater.,Nat. Prod. Rep.,Chem. Sci.,及Cell子刊Chem. Biol.等国际知名期刊发表SCI论文20余篇,撰写英文学术专著1个章节,先后申请1项欧盟专利和1项PCT国际专利,共被引用1000多次。多篇论文被Deutschlandfunk(德意志广播电台),Chemistry World,Cheminform,Chin. J. Org. Chem.等期刊广播媒体作专文评论、亮点报道和摘录。作为项目负责人,目前主持国家“千人计划”青年项目,上海市浦江人才计划,教育部基本科研业务费探索基金和中科院上海有机所生命有机化学国家重点实验室开放基金等研究项目。
 
研究方向
1. 复杂寡糖和糖缀合物的合成方法学、全合成和化学生物学
2. 糖类药物和糖类疫苗的开发
3. 糖与蛋白质相互作用机理的研究及其在新型医疗诊断工具中的应用
 
招生情况
本课题组热忱欢迎有志于糖化学和糖类药物研究的博士后、博士生、硕士生、本科生和研究助理加入我们的研究队伍,期待有意向的校内外青年学子随时来参观我们的实验室或者电话邮件联系。
 
发表论文
 
22. Chen, X.; Shen, D.; Wang, Q.; Yang, Y.; Yu, B.* ortho-(Methyltosylaminoethynyl)benzyl Glycosides as New Glycosyl Donors for Latent-active Glycosylation. Chem. Commun. 2015, 51, 13957–13960.
21. Yang, Y.;* Zhang, X.; Yu, B.* O-Glycosylation Methods in the Total Synthesis of Complex Natural Glycosides. Nat. Prod. Rep. 2015, 32, 1331–1355.
•      Abstracted by Cheminform 2015, 43-237
•      ESI "Highly Cited Paper"
20. Yang, Y.;* Lian, G.; Yu, B.* Naturally Occurring Polyphenolic Glucosidase Inhibitors. Isr. J. Chem. 2015, 55, 268–284. (Chi-Huey Wong – Wolf Prize Special Issue)
•      Abstracted by Cheminform 2015, 24-287
19. Reinhardt, A.;† Yang, Y.;† Claus, H.; Pereira, C. L.; Cox, A. D.; Vogel, U.; Anish, C.;* Seeberger, P. H.* Antigenic Potential of a Highly Conserved Neisseria meningitidis Lipopolysaccharide Inner Core Structure Defined by Synthetic Approach. Chem. Biol. 2015, 22, 38–49. (†: co-first author)  
18. Yang, Y.;* Laval, S.; Yu, B.* Chemical Synthesis of Saponins. Adv. Carbohydr. Chem. Biochem. 2014, 71, 137–226.
 17. Xu, P.; Xu, W.; Dai, Y.; Yang, Y.; Yu, B.* Efficient Synthesis of a Library of Heparin Tri- and Tetrasaccharides Relevant to the Substrate of Heparanase. Org. Chem. Front. 2014, 1, 405–414.
16. Broecker, F.; Aretz, J.; Yang, Y.; Hanske, J.; Guo, X.; Reinhardt, A.; Wahlbrink, A.; Rademacher, C.; Anish, C.;* Seeberger, P. H.* Epitope Recognition of Antibodies against a Yersinia pestis Lipopolysaccharide Trisaccharide Component. ACS Chem. Biol. 2014, 9, 867–873.
15. Yang, Y.;* Yu, B.* Recent Advances in the Synthesis of Chitooligosaccharides and Congeners. Tetrahedron 2014, 70, 1023–1046.
•      Abstracted by Cheminform 2014, 17-257
14. Yang, Y.; Oishi, S.; Martin, C. E.; Seeberger, P. H.* Diversity-oriented Synthesis of Inner Core Oligosaccharides of the Lipopolysaccharide of Pathogenic Gram-negative Bacteria. J. Am. Chem. Soc. 2013, 135, 6262–6271. 
13. Yang, Y.; Martin, C. E.; Seeberger, P. H.* Total Synthesis of the Core Tetrasaccharide of Neisseria meningitidis Lipopolysaccharide, a Potential Vaccine Candidate for Meningococcal Diseases. Chem. Sci. 2012, 3, 896–899.
•      Broadcasted on German National Radio ‘‘Deutschlandfunk’’ (30 Dec. 2011)
•      Highlighted in Chemistry World (February 2012)
12. Yang, Y.; Liu, T.; Yang, Y.; Wu, Q.; Yang, Q.;* Yu, B.* Synthesis, Evaluation, and Mechanism of N,N,N-Trimethyl-D-glucosamine-(1→4)-chitooligosaccharides as Selective Inhibitors of Glycosyl Hydrolase Family 20 beta-N-Acetyl-D-hexosaminidases. ChemBioChem 2011, 12, 457–467. 
11. Yang, Y.; Li, Y.; Yu, B.* Chemoselective Glycosylation of Carboxylic Acid with Glycosyl ortho-Hexynylbenzoates as Donors. Tetrahedron Lett. 2010, 51, 1504–1507.  
10. Li, Y.; Yang, X.; Liu, Y.; Zhu, C.; Yang, Y.; Yu, B.* Gold(I)-catalyzed Glycosylation with Glycosyl ortho-Alkynylbenzoates as Donors, General Scope and Application to the Synthesis of a Cyclic Triterpene Saponin. Chem. Eur. J. 2010, 16, 1871–1882.
•      Abstracted by Cheminform 2010, 24-183
9. Yang, Y.; Li, Y.; Yu, B.* Total Synthesis and Structure Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal beta-N-Acetylglucosaminidases. J. Am. Chem. Soc. 2009, 131, 12076–12077.
•      Highlighted in Chin. J. Org. Chem. 2009, 29, 1867
•      Abstracted by Cheminform 2009, 51-199
8. Li, Y.; Yang, Y.; Yu, B.* An Efficient Glycosylation Protocol with Glycosyl ortho-Alkynylbenzoates as Donors under the Catalysis of PPh3AuOTf. Tetrahedron Lett. 2008, 49, 3604–3608.
•      Abstracted by Cheminform 2008, 36-196 
7. Yang, Y.; Yu, B.* N-Dimethylphosphoryl-Protection in the Efficient Synthesis of Glucosamine-containing Oligosaccharides with Alternate N-acyl Substitutions. Tetrahedron Lett. 2007, 48, 7049–7052.  
6. Yang, Y.; Yu, B.* N-Dimethylphosphoryl-Protected Glucosamine Trichloroacetimidate as an Effective Glycosylation Donor. Tetrahedron Lett. 2007, 48, 4557–4560.
•      Abstracted by Cheminform 2007, 41-173 
5. Liu, Z.; Hu, Z.; Liang, J.; Li, S.; Yang, Y.; Peng, S.; Qian, Y.* Size-Controlled Synthesis and Growth Mechanism of Monodisperse Tellurium Nanorods by a Surfactant-Assisted Method. Langmuir 2004, 20, 214–218.  
4. Liu, Z.; Li, S.; Yang, Y.; Peng, S.; Hu, Z.; Qian, Y.* Complex-Surfactant-Assisted Hydrothermal Route to Ferromagnetic Nickel Nanobelts. Adv. Mater. 2003, 15, 1946–1948.  
3. Liu, Z.; Peng, S.; Xie, Q.; Hu, Z.; Yang, Y.; Zhang, S.; Qian, Y.* Large-scale Synthesis of Ultralong Bi2S3 Nanoribbons via a Solvothermal Process. Adv. Mater. 2003, 15, 936–940.  
2. Liu, Z.; Li, S.; Yang, Y.; Hu, Z.; Peng, S.; Liang, J.; Qian, Y.* Shape-controlled Synthesis and Growth Mechanism of One-dimensional Nanostructures of Trigonal Tellurium. New J. Chem. 2003, 27, 1748–1752.
•      Abstracted by Cheminform 2004, 16-207 
1. Liu, Z.; Yang, Y.; Liang, J.; Hu, Z.; Li, S.; Peng, S.; Qian, Y.* Synthesis of Copper Nanowires via a Complex-Surfactant-Assisted Hydrothermal Reduction. J. Phys. Chem. B 2003, 107, 12658–12661.
 
专利
2. Seeberger, P. H.; Yang, Y.; Anish, C.; Reinhardt, A. Total Synthesis and Immunological Evaluation of Saccharide Moieties of the Lipopolysaccharide from Neisseria meningitidis. PCT Int. Appl. (2013), WO 2013041732 A1.
1. Seeberger, P. H.; Yang, Y.; Anish, C.; Reinhardt, A. Total Synthesis of the Core Tetrasaccharide of the Lipopolysaccahride from Neisseria meningitidis. Eur. Pat. Appl. (2013), EP 2573100 A1.

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