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姓 名:朱丽丽
职 称:副教授
电 话:021-64253379
传 真:
email :zhulfl@ecust.edu.cn

人物详情

2008年7月毕业于中科院福建物质结构研究所获博士学位,专业为生物化学与分子生物学。
2008年8月至2011年7月在德国吕贝克大学生物化学系做博士后研究。
2011年8月至今在华东理工大学药学院任副教授。
研究方向:主要从事与疾病有关蛋白质的结构生物学和化学生物学方面研究。
结构生物学研究: 以X射线结晶学为主要手段,研究与疾病有关蛋白质的晶体结构,研究大分子结构和功能的关系,为理性设计创新药物提供结构基础。
化学生物学研究: 基于靶标蛋白的小分子抑制剂筛选研究。

科研成果:   
1)          Junsheng Zhu, Le Han, Yanyan Diao, Xiaoli Ren, Minghao Xu, Liuxin Xu, Shiliang Li, Qiang Li , Dong Dong, Jin Huang, Xiaofeng Liu, Zhenjiang Zhao, Rui Wang, Lili Zhu*, Yufang Xu, Xuhong Qian *, and Honglin Li*.Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase. J. Med. Chem. 2015, 58(3), 1123-1139.
2)          Liyan Wang, Shoude Zhang, Junsheng Zhu, Lili Zhu, Xiaofeng Liu, Lei Shan, Jin Huang*, Weidong Zhang*, Honglin Li*. Identification of Diverse Natural Products as Falcipain-2 Inhibitors through Structure-based Virtual Screening. Bioorg. Med. Chem. Lett. 2014. 24(5) : 1261–1264.
3)          Minghao Xu, Junsheng Zhu, Yanyan Diao, Hongchang Zhou, Xiaoli Ren, Deheng Sun, Jin Huang, Dongmei Han, Zhenjiang Zhao, Lili Zhu*, Yufang Xu*, and Honglin Li*. Novel Selective and Potent Inhibitors of Malaria Parasite Dihydroorotate Dehydrogenase: Discovery and Optimization of Dihydrothiophenone Derivatives. J. Med. Chem., 2013. 56 (20) : 7911–7924
4)          Xiaojuan Yu, Xue Zhao, Lili Zhu, Chuanxin Zou, Xiaofeng Liu, Zhenjiang Zhao, Jin Huang* and Honglin Li*. Discovery of novel inhibitors for human farnesyltransferase (hFTase) via structure-based virtual screening. Med. Chem. Commun., 2013. 4 : 962-971
5)          Liyan Wang, Chunmei Yang, Weiqiang Lu, Li Liu, Rui Gao, Sha Liao, Lili Zhu, Zhenjiang Zhao, Yufang Xu, Honglin Li*, Jin Huang, Weiping Zhu. Discovery of New Potent Inhibitors for Carbonic Anhydrase IX by Structure-Based Virtual Screening. Bioorg. Med. Chem. Lett.., 2013. 23 : 3496-3499
6)          Yuwei Song, Huangtao Jin, Xiaofeng Liu, Lili Zhu*, Jin Huang*, Honglin Li*. Discovery of non-peptide inhibitors of Plasmepsin II by structure-based virtual screening. Bioorg. Med. Chem. Lett., 2013. 23(7) : 2078-2082
7)          Xianwen Cao, Jing Jiang, Shoude Zhang, Lili Zhu, Juan Zou, Yanyan Diao, Weilie Xiao, Lei Shan, Handong Sun, Weidong Zhang*, Jin Huang*, Honglin Li*. Discovery of Natural Estrogen Receptor Modulators with Structure-based Virtual Screening. Bioorg. Med. Chem. Lett., 2013. 23 : 3329-3333
8)          Kunqiang Cui1, Weiqiang Lu1, Lili Zhu1, Xu Shen, Jin Huang. Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pulori peptide deformylase activity. Biochem. Biophys. Res. Commun., 2013. 435(2):289-294
9)          Lili Zhu, Shyla George, Marco F.Schmidt, Samer I Al-Gharabli, Jorg Rademann, Rolf Hilgenfeld. Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral research. 2011, 92 (2),204-216.
10)       Lili Zhu, Cai Yuan, Zhuo Chen, Wanyu Wang, Mingdong Huang. Expression, purification and characterization of recombinant Jerdonitin, a P-II class snake venom metalloproteinase comprising metalloproteinase and disintegrin domains. Toxicon, 2010, 55, 375-380.
11)       Lili Zhu, Feng Yang, Liqing Chen, Edward J.Meehan, Mingdong Huang. A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography. Journal of structural biology.2008, 162, 40-49.

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