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姓 名:刘建文
职 称:教授
电 话: 021-64252044,021-64252262
传 真:021-64252044
email : liujian@ecust.edu.cn

人物详情

      1994年毕业于上海中医药大学肿瘤治疗学专业,获得医学博士学位;1995年应日本国科学技术厅邀请,作为STA Fellow在大阪生物科学研究所(Osaka Bioscience Institute)和日本理化学研究所(Institute of Physical and Chemical Research)进行客座研究。研究天然药物对血管内皮细胞纤溶活性因子的基因调空作用。2001年毕业于日本广岛大学(省立)遗传子制御工学研究室,研究自由基与癌转移的过程及实验药物干预的分子机理,获得应用生物科学博士学位。现主要研究领域涉及的领域:分子细胞药理学,毒理学,肿瘤学,细胞生物学,分子生物学,中药学。现主要研究方向:细胞周期阻滞及凋亡诱导剂的发现与作用机理研究;肿瘤细胞凋亡小RNA表达、调控的研究及其在新药研发中的应用;基于肿瘤光动力的分子模型的建立及先导化合物的发现研究;纳米材料与技术在生命科学中的应用基础研究。先后主持和参与国家和省部级科研课题。先后参与获省部级科研成果1等奖2项,2等奖4项、3等奖2项,申请发明专利11项,国际发明专利1项,发表国内外论文近120篇,其中SCI收录64篇。主编《药理实验方法学—新技术与新方法》,《生物资源中活性物质的开发与利用》等4部著作。

近年发表论文

1. Shengchao Lin, Kecheng Lei, Wenpei Du, Liyan Yang, Haiyang Shi, Yuwei Gao, Peihao Yin, Xin Liang, Jianwen Liu*: Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. The International Journal of Biochemistry & Cell Biology 2016,71: 24-34

2. Yuanhong Zheng, Guifang Yin, Vanminh Le, Anle Zhang, Peihao Yin, Jianwen Liu*, Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, Which Generates Vaccine for Cancer Therapy Int J Biol Sci  2016; 12(1): 120-132

3. Liyan Yang, Qiannan Liang, Ke Shen, Li Ma, Na An, Weiping Deng, Zhewei Fei, Jianwen Liu:A novel class I histone deacetylase inhibitor, I-7ab, induce apoptosis and arrest cell cycle progression in human colorectal cancer cells. Biomedicine & Pharmacotherapy  2015,71: 70-78

4. Van-Minh Le, Jing-Jing Wang, Ming Yuan, The-Long Nguyen, Gui-Fang Ying, Yuan-Hong Zheng, Wei-Bin Shi, Mei-Dong Lang, Lei-Ming Xu, Jian-Wen Liu: An investigation of antitumor efficiency of novel sustained and targeted 5-fluorouracil Nanoparticles. European Journal of Medicinal Chemistry  2015, 92: 882-889

5. Yuanhong Zheng, Fangyuan Zou, Jingjing Wang, Guifang Yin, Vanminh Le, Zhewei Fei, and Jianwen Liu*: Photodynamic Therapy-mediated Cancer Vaccination Enhances Stem-like Phenotype and Immune Escape, Which Can Be Blocked by Thrombospondin-1 Signaling through CD47 Receptor Protein. J Biol Chem. 2015, 290: 8975-8986.

6. Kecheng Lei & Shaoying Tan & Wenpei Du & Yichun Xu & Shengchao Lin & Yuanhong Zheng & Fangyuan Zou &Yufang Xu & Jianwen Liu:3B, a novel of photosensitizer, exhibited anti-tumor effects via mitochondrial apoptosis pathway in MCF-7 human breast carcinoma cells. Tumor Biol. 2015, 36:5597–5606

7. Rurong Mao, Fangyuan Zou, Liyan Yang, Shengchao Lin, Yueqi Li, Mingxing Ma, Peihao Yin, Xin Liang, Jianwen Liu*: The Loss of MiR-139-5p Promotes Colitis-Associated Tumorigenesis by Mediating PI3K/AKT/Wnt Signaling International Journal of Biochemistry and Cell Biology 2015,69:153–161

8. Li Ma, Rurong Mao, Ke Shen, Yuanhong Zheng, Yueqi Li, Jianwen Liu*, Lei Ni: Atractylenolide I-mediated Notch Pathway Inhibition Attenuates Gastric Cancer Stem Cell Traits. Biochemical and Biophysical Research Communications   2014, 450: 353–359

9. Ke Shen, Li Ma, Yi Li, Yanyan Qiu, Daling Cui, Yanhua Lu, Peihao Yin, Jianwen Liu*: A Post-Transcriptional Regulation of Tumor Suppressor MiR-139-5p and A Network of MiR-139-5p Mediated mRNAs Interactions in Colorectal Cancer. FEBS Journal 281 (2014) 3609–3624

10. Zujun Que, Fangyuan Zou, Anle Zhang, Yuanhong Zheng, Ling Bi, Jian-Jiang Zhong, Jianhui Tian, Jianwen Liu,* Ganoderic acid Me induces the apoptosis of competent T cells and increases the proportion of Treg cells through enhancing the expression and activation of Indoleamine 2,3-Dioxygenase in Mouse Lewis Lung Cancer Cells. International Immunopharmacology  2014,23: 192–204

11. Anle Zhang, Yuanhong Zheng, Zujun Que, Lingling Zhang, Shengchao Lin, Vanminh Le, Jianwen Liu*, Jianhui Tian: Astragaloside IV inhibits progression of lung cancer via mediate immune function of Tregs and CTLs by interfere with IDO. J Cancer Res Clin Oncol 2014, 140:1883-1890

12. Shengchao Lin, Kecheng Lei, Lingling Zhang, Yanhua Lu, Ping Liu, Jianwen Liu*: Development of a multifunctional luciferase reporters system for assessing Endoplasmic Reticulum-locating anti-tumor photosensitive compounds. Cell Stress & Chaperones 2014, 19:927–937

13. Lei Liang, Sheng Xie, Lin Jiang, Hui Jin, Songgang Li, Jianwen Liu*: The Combined Effects of Hematoporphyrin monomethyl ether-SDT and Doxorubicin on the proliferation of QBC cell lines. Ultrasound in Med. & Biol., 2013; (39) 1:146–160

14. Ke Xu, Xin Liang, Daling Cui, Yixin Wu, Weibin Shi and Jianwen Liu*: miR-1915 Inhibits Bcl-2 to Modulate Multidrug Resistance by Increasing Drug-Sensitivity in Human Colorectal Carcinoma Cells.  Mol Carcinogen  52:70–78 (2013)

15. Ke Shen, Liyun Sun, Huanying Zhang, Yufang Xu, Xuhong Qian, Yanhua Lu, Qi Li, Lei Ni, Jianwen Liu*: A ROS-mediated lysosomal–mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells. Cancer Letters  2013,333: 229–238

16. Yuanhong Zheng & Vanminh Le & Zhuoan Cheng & Sheng Xie & Hegeng Li & Jianhui Tian and Jianwen Liu*: Development of rapid and highly sensitive HSPA1A promoter-driven luciferase reporter system for assessing oxidative stress associated with low-dose photodynamic therapy Cell Stress and Chaperones  2013,18:203–213

17. Hui Jin, Lei Liang, Li-Feng Liu, Wei-Ping Deng, and Jianwen Liu*: HDAC Inhibitor DWP0016 Activates p53 Transcription and Acetylation to Inhibit Cell Growth in U251 Glioblastoma Cells.  J Cell Biochem  2013,114:1498–1509

18. Zhuoan Cheng & Shaobo Qiu & Lin Jiang & Anle Zhang & Wenjing Bao & Ping Liu & Jianwen Liu*: MiR-320a is Downregulated in Patients with Myasthenia Gravis and Modulates Inflammatory Cytokines Production by Targeting Mitogen-activated Protein Kinase 1 J Clin Immunol  2013, 33:567–576

19. Yichun Xu, Zijing Jiang, Peihao Yin, Qi Li, Jianwen Liu,*: Role for Class I histone deacetylases in multidrug resistance  Exp Cell Res 318  (2012) 117-186

20. Ke Shen,1 Daling Cui, Liyun Sun, Yanhua Lu, Mingquan Han, and Jianwen Liu* Inhibition of IGF-IR Increases Chemosensitivity in Human Colorectal Cancer Cells Through MRP-2 Promoter Suppression J Cell Biochem 113:2086–2097 (2012)

21. Ke Shen, Qiannan Liang, Ke Xu, Daling Cui, Lin Jiang, Peihao Yin, Yanhua Lu, Qi Li, Jianwen Liu*: MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I  insulin-like growth factor receptor Biochem Pharmacol  84  (2012)  320–330

22. Ke Xu, Xin Liang, Ke Shen, Daling Cui, Yuanhong Zheng,Jianhua Xu, Zhongze Fan, Yanyan Qiu, Qi Li, Lei Ni, Jianwen Liu*: MiR-297 modulate multidrug resistance in human colorectal carcinoma by down-regulating MRP-2.  Biochem J 2012, 446(2): 291-300.

23. Ke Xu, Xin Liang, Ke Shen, Liyun Sun, Daling Cui, Yuxia Zhao, Jianhui Tian, Lei Ni, Jianwen Liu*: MiR-222modulatesmultidrug resistance in human colorectal carcinoma by down-regulating ADAM-17  Exp Cell Res 318 (2012) 2168–2177

24. Yiquan Li, Jin Shao, Ke Shen, Yufang Xu, Jianwen Liu,* and Xuhong Qian* E2F1-Depend ent Pathways are Involved in Amonafide Analogue 7-d-Induced DNA Damage, G2/M Arrest and Apoptosis in p53-Deficien t K562 Cells  J Cell Biochem 113(2012):3165–3177

25. Xin Liang , Ke Xu, Yufang Xu, Jianwen Liu*, Xuhong Qian: B1-induced caspase-independent apoptosis in MCF-7 cells is mediated by down-regulation of Bcl-2 via p53 binding to P2 promoter TATA box. Toxicol Appl Pharm  256 (2011) 52–61

26. Xin Liang, Lei Guo, Ke Xu, Tiantian Jin, Yixin Wu, Ping Liu, and Jianwen Liu*: Synthesis of Immunomagnetic Nanoparticles and Their Use for Breast Cancer Cell Separation Advanced Science Letters  Vol. 4, 1–5, (2011)

27. Lijuan Sun, Lin Zhou, Mingcang Chen, Renqian Zhong, and Jianwen Liu*: Amelioration of Systemic Lupus Erythematosus by Withangulatin A in MRL/lpr Mice J Cell Biochem 112:2376–2382 (2011)



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