梁欣



梁欣 博士

副教授，硕士生导师

邮箱：xin.liang@ecust.edu.cn

地址：上海市徐汇区梅陇路130号实验十八楼633室；

邮编：200237

 

个人简历：

2003年9月-2007年6月 华东理工大学生物工程专业，工学学士

2007年9月-2012年3月 华东理工大学生物化工专业，工学博士

2012年7月-2015年5月 美国埃默里大学（Emory University）Renhao Li’s Lab 博士后

2015年7月-2016年8月 华东理工大学药学院，讲师

2016年9月至今            华东理工大学药学院，副教授

现主持国家自然科学基金青年基金一项，主持教育部基本科研业务费探索研究基金一项。


研究方向：

主要研究领域为肿瘤转移以及微环境的相互作用研究。包括血小板参与肿瘤转移微环境形成的机制研究，miRNA在肿瘤转移以及微环境中的相互作用研究，小分子化合物或抗体药物的抗肿瘤机制研究。


代表性论文：

  1. Liang X, Chen W, Shi H, Gu X, Li Y, Qi Y, Xu K*, Zhao A*, Liu J*. PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing. Cell Death & Disease. 2018, 9:569. IF:5.965

  2. Liang X, Shi H, Yang L, Qiu C, Lin S, Qi Y, Li J*, Zhao A*, Liu J*. Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. Br J Cancer. 2017 Mar 28;116(7):903-911. IF: 6.176.

  3. Liang X, Wang J, Chen W, Ma X, Wang Y, Nagao N, Weng W*, Huang J*, Liu J*. Inhibition of airway remodeling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model. Biomed Pharmacother. 2017 Aug 26;95:275-286. IF: 2.759

  4. Xu K*, Chen G, Qiu Y, Yuan Z, Li H, Yuan X, Sun J, Xu J, Liang X*, Yin P*. MiR-503-5p confers drug resistance by targeting PUMA in colorectal carcinoma. Oncotarget. 2017 Mar 28;8(13):21719-21732. IF: 5.168

  5. Xu K, Chen G, Li X, Wu X, Chang Z, Xu J, Zhu Y, Yin P, Liang X*, Dong L*. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling. Sci Rep. 2017, 7:41718. IF: 4.259

  6. Lin S, Yang L, Shi H, Du W, Qi Y, Qiu C, Liang X*, Shi W*, Liu J*. Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. Int J Biochem Cell Biol. 2017 Jun;87: 54-68. IF: 3.505

  7. Chen W, Ma X, Zhang P, Li Q, Liang X*, Liu J*. MiR-212-3p inhibits LPS-induced inflammatory response through targeting HMGB1 in murine macrophages. Exp Cell Res. 2017, 350(2):318-26. IF: 3.564

  8. Chen W1, Liang X1, Syed AK, Jessup P, Church WR, Ware J, Josephson CD, Li R*. Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage. Arterioscler Thromb Vasc Biol. 2016, 36(9):1821-8. IF: 6.607

  9. Liang X, Syed AK, Russell SR, Ware J, Li R*. Dimerization of glycoprotein Ib is not sufficient to induce platelet clearance. J Thromb Haemost. 2016,14: 381-6. IF: 5.287

  10. Liang X, Yin G, Ma Y, Xu K*, Liu J*, Li J*. The critical role of mast cell-derived hypoxia-inducible factor-1α in regulating mast cell function. J Pharm Pharmacol. 2016, 68(11):1409-16. IF: 2.405

  11. Zhou L1, Liang X1, Zhang L, Yang L, Nagao N, Wu H, Liu C, Lin S, Cai G*, Liu J*. MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2. Oncotarget. 2016, 7(32): 51943-54. IF: 5.168

  12. Li Q1, Liang X1, Wang Y, Meng X, Xu Y, Cai S, Wang Z*, Liu J*, Cai G*. miR-139-5p Inhibits the Epithelial- Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2. Sci Rep. 2016, 6: 27157. IF: 4.259

  13. Zou F, Mao R, Yang L, Lin S, Lei K, Zheng Y, Ding Y, Zhang P, Cai G*, Liang X*, Liu J*. Targeted deletion of miR-139-5p activates MAPK, NF-kB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer. FEBS J. 2016, 283(8): 1438-52. IF: 3.902

  14. Lei K, Du W, Lin S, Yang L, Xu Y, Gao Y, Xu B, Tan S, Xu Y, Qian X, Liang X*, Liu J*. 3B, a novel photosensitizer, inhibits glycolysis and inflammation via miR-155-5p and breaks the JAK/STAT3/SOCS1 feedback loop in human breast cancer cells. Biomed Pharmacother. 2016, 82: 141-50. IF: 2.759

  15. Zheng Y, Yin G, Le V, Zhang A, Chen S, Liang X*, Liu J*. Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy. Int J Biol Sci. 2016, 12(1): 120-32. IF: 3.873

  16. Lin S, Lei K, Du W, Yang L, Shi H, Gao Y, Yin P*, Liang X*, Liu J*. Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. Int J Biochem Cell Biol. 2016, 71:24-34. IF: 3.505

  17. Mao R, Zou F, Yang L, Lin S, Li Y, Ma M, Yin P*, Liang X*, Liu J*. The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. Int J Biochem Cell Biol. 2015, 69: 153-61. IF: 3.905

  18. Liang X, Russell SR, Estelle S, Jones LH, Cho S, Kahn ML, Berndt MC, Bunting ST, Ware J, Li R*. Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site. J Thromb Haemost. 2013, 11(12): 2155-62 IF: 5.55


注：1共同第一作者， ＊通讯作者
网页发布时间: 2019-06-18