赵玉政

赵玉政教授 博士生导师

教育部国家级高层次人才

电话/传真：021-64251287

通讯地址：上海市徐汇区梅陇路130号实验18楼733室；邮编：200237

【个人简介】：

赵玉政，教授，博士生导师，北京协和医院博士生导师，上海市细胞代谢光遗传学技术前沿科学研究基地主任，中国医学科学院细胞代谢监测成像新技术创新单元主任，教育部国家级高层次人才（2021），国家重点研发计划首席科学家（2019），教育部国家级青年人才（2017），国家优秀青年科学基金获得者（2017），国家自然科学基金创新研究群体核心成员，中国细胞生物学学会细胞代谢专业委员会委员，中国生物化学与分子生物学会代谢专业委员会委员，中国细胞生物学学会衰老细胞生物学专业委员会委员，中国老年学和老年医学学会抗衰老分会委员，中国老年学和老年医学学会老年病学分会衰老基础医学专家委员会常务委员，中国抗癌协会肿瘤代谢专业委员会委员，中国医药生物技术协会神经修复与再生专业委员会委员，中国衰老标志物研究联合体专家委员会委员，中国研究型医院学会过敏医学专业委员会副主任委员，长三角现代产业学院协同育人联盟生物医药专家委员会副主任委员，上海市生物化学与分子生物学学会副理事长，上海市细胞生物学学会理事，上海市产医融合战略咨询委员会委员，上海市产医融合战略咨询委员会肿瘤治疗专业委员会委员等。主要成果发表在Nature Methods、Cell Metabolism (4篇)、Nature Metabolism (2篇)、Nature Structural & Molecular Biology (2篇)、Nature Protocols (3篇)、Developmental Cell、Science Advances (2篇)、Cell Reports、PNAS、Blood、Trends in Cell Biology等国际权威期刊，编写英文著作Methods in Enzymology1个章节。已申请50余项中国发明专利（授权20项）和10余项国际发明专利（授权3项），获教育部自然科学一等奖（2020）、上海青年科技英才奖（2018）、上海市青少年科技创新“市长”奖（2013）等荣誉。研究成果在国际上产生重要影响，相关技术已被全球来自哈佛大学、斯坦福大学、麻省理工学院、牛津大学、剑桥大学及中国科学院等600多个实验室跟踪应用，典型技术应用发表于Science、Cell。

【研究方向】：

1、细胞代谢原位检测与成像技术开发

2、细胞代谢调控机制研究

3、衰老及相关疾病（肿瘤、糖尿病、肥胖、心脑血管疾病等）创新药物开发

【研究生招生】：

本实验室研究对象涉及基因、蛋白质、细菌、哺乳动物细胞、线虫、斑马鱼、果蝇和小鼠，研究领域涉及药学、药理学、细胞生物学、生物化学与分子生物学、合成生物学、光遗传学、化学遗传学、化学生物学等。我们热忱欢迎有志于从事细胞代谢及代谢性疾病候选药物开发方面研究的同学加盟本实验室。

【代表性论文】（*通讯作者）：

1. Li, R., Li, Y., Jiang, K., Zhang, L., Li, T., Zhao, A., Zhang, Z., Xia, Y., Ge, K., Chen, Y., Wang, C., Tang, W., Liu, S., Lin, X., Song, Y., Mei, J., Xiao, C., Wang, A., Zou, Y., Li, X., Chen, X., Ju, Z., Jia, W., Loscalzo, J., Sun, Y., Fang, W.*, Yang, Y.*, Zhao Y.*. Lighting up arginine metabolism reveals its functional diversity in physiology and pathology. Cell Metabolism, 2025, 37(1), 291-304 (Cover story).

2. Wang, A., Zou, Y., Liu, S., Zhang, X., Li, T., Zhang, L., Wang, R., Xia, Y., Li,X., Zhang, Z., Liu, T., Ju,Z., Wang, R.*, Loscalzo, J., Yang, Y.*, Zhao, Y.*. Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors. Nature Protocols, 2024, 19(5), 1311-1347.

3. He, J., Wang, A., Zhao, Q., Zou, Y., Zhang, Z., Sha, N., Hou, G., Zhou, B., Yang, Y., Chen, T., Zhao, Y.*, Jiang, Y.*. RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth. Nature Structural & Molecular Biology, 2024, 31(9), 1413-1425.

4. Zhao, Y.*, Jiang, Y.*. HES4 controls redox balance and supports pyrimidine synthesis and tumor growth. Nature Structural & Molecular Biology, 2024, 31(9), 1315-1316.

5. Li, X., Zhang, Y., Xu, L., Wang, A., Zou, Y., Li, T., Huang, L., Chen, W., Liu, S., Jiang, K., Zhang, X., Wang, D., Zhang, L., Zhang, Z., Zhang, Z., Chen, X., Jia, W., Zhao, A., Yan, X., Zhou, H., Zhu, L., Ma, X., Ju, Z., Jia, W., Wang, C.*, Loscalzo, J., Yang, Y.*, Zhao, Y.*. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease. Cell Metabolism, 2023, 35(1), 200-211.

6. Dou, X., Fu, D., Long, Q., Liu, S., Zou, Y., Fu, D., Xu, Q., Jiang Z., Ren, X., Zhang, G., Wei X., Li Q., Campisi, J., Zhao, Y.*, Sun Y.*. PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy. Nature Metabolism, 2023, 5, 1887-1910.

7. Jia, M., Yue, X., Sun, W., Zhou, Q., Chang, C., Gong, W., Feng, J., Li, X., Zhan, R., Mo, K., Zhang, L., Qian, Y., Sun, Y., Wang, A., Zou, Y., Chen, W., Li, Y., Huang, L., Yang, Y.*, Zhao, Y.*, Cheng, X.*. ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation. Science Advances, 2023, 9, eadg4993.

8. Huang, D., Zhang, C., Xiao, M., Li, X., Chen, W., Jiang, Y., Yuan, Y., Zhang, Y., Zou, Y., Deng, L., Wang, Y., Sun, Y., Dong, W., Zhang, Z., Xie, L., Yu, Z., Chen, C., Liu, L., Wang, J., Yang, Y.*, Yang, J.*, Zhao, Y.*, Zheng, J.*. Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells. PNAS, 2023, 120 (13), e2210796120.

9. Chen, C.*, Lai, X., Xie, L., Yu, Z., Dan, S., Jiang, Y., Chen, W., Liu, L., Yang, Y., Zhang, Y., Huang, D.*, Zhao, Y.*, Zheng J.*. NADPH metabolism determines the leukemogenic capacity and drug resistance of AML cells. Cell Reports, 2022, 39(1), 110607.

10. Ma, C., Zheng K., Jiang, K., Zhao, Q., Sha, N., Wang, W., Yan, M., Chen, T., Zhao, Y.*, Jiang, Y.*. The alternative activity of nuclear PHGDH contributes to tumor growth under nutrient stress. Nature Metabolism, 2021, 3(10), 1357-1371.

11. Chen, C., Hao X., Lai X., Liu L., Zhu J., Shao H., Huang D., Gu H., Zhang T., Yu Z., Xie L., Zhang X., Yang Y., Xu J.*, Zhao Y.*, Lu Z.*, Zheng J.*. Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B-cell acute lymphoblastic leukemia. Science Advances, 2021, 7, eabd6280.

12. Zou, Y., Wang, A., Huang, L., Zhu, X., Hu, Q., Zhang, Y., Chen, X., Li, F., Wang, Q., Wang, H., Liu, R., Zuo, F., Li, T., Yao, J., Qian, Y., Shi, M., Yue, X., Chen, W., Zhang, Z., Wang, C., Zhou, Y., Zhu, L., Ju, Z., Loscalzo, J., Yang, Y.*, Zhao, Y.*. Illuminating NAD⁺ metabolism in live cells and in vivo using a genetically encoded fluorescent sensor. Developmental Cell, 2020, 53(2), 240-252.

13. Gu, H., Chen, C., Hao, X., Su, N., Huang, Dan., Zou, Y., Lin, S., Chen, X., Zheng, D., Liu, L., Yu, Z., Xie, L., Zhang, Y., He, X., Lai, X., Zhang, X., Chen, G., Zhao, Y.*, Yang, Y.*, Loscalzo, J., Zheng, J.*. MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells. Blood, 2020, 136 (5), 553-571.

14. Zou, Y., Wang, A., Shi, M., Chen, X., Liu, R., Li, T., Zhang, C., Zhang, Z., Zhu, L., Ju, Z., Loscalzo, J., Yang, Y.*, Zhao, Y.*. Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded ﬂuorescent sensors. Nature Protocols, 2018, 13(10), 2362-2386.

15. Tao, R.^#, Zhao, Y.^#, Chu, H.^#, Wang, A., Zhu, J., Chen, X., Zou, Y., Shi, M., Liu, R., Su, N., Du, J., Zhou, H., Zhu, L., Qian, X., Liu, H., Loscalzo, J., and Yang, Y. Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism. Nature Methods, 2017, 14(7), 720-728.

16. Zhao, Y., Wang, A., Zou, Y., Su, N., Loscalzo, J., and Yang, Y. In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD⁺/NADH redox state. Nature Protocols, 2016, 11(8), 1345-1359 (Cover story).

17. Zhao, Y., Hu, Q., Cheng, F., Su, N., Wang, A., Zou, Y., Hu, H., Chen, X., Zhou, H., Huang, X.,Yang, K., Zhu, Q., Wang, X., Yi, J., Zhu, L., Qian, X., Chen, L., Tang, Y., Loscalzo, J., and Yang, Y. SoNar, a highly responsive NAD⁺/NADH sensor, allows high-throughput metabolic screening of anti-tumor agents. Cell Metabolism, 2015, 21(5), 777-789.

18. Zhao, Y., Jin, J., Hu, Q., Zhou, H.M., Yi, J., Yu, Z., Xu, L., Wang, X., Yang, Y., and Loscalzo, J. Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metabolism, 2011, 14(4), 555-566.

【著作】：

1. Zhao, Y., Yang, Y., and Loscalzo, J.Real-Time Assessment of the Metabolic Profile of Living Cells with Genetically Encoded NADH Sensors. Methods in Enzymology, 2014, 542, 349-367. (ISBN：978-0-12-416618-9)