郑文云，博士，副教授、硕士生导师、药物科学系副主任

联系方式：

通讯地址：上海市梅陇路130号318信箱，邮编200237

电话：（021）64253980；13641936878.

电邮：zwy@ecust.edu.cn；

个人简历：

郑文云，理学博士，华东理工大学 药学院/上海市新药设计重点实验室，副教授，硕士研究生导师，上海市优秀青年骨干教师。2006毕业于沈阳药科大学获博士学位，师从杨胜利院士；2013年美国明尼苏达大学（University of Minnesota）访问留学一年。

  研究领域\方向、学术兼职和荣誉奖励：

研究领域：生物药物\\药理药效与药剂学；研究方向：抗肿瘤新药研发、评价及转载系统研究。

学术兼职：Biochemistry and Molecular Biology编委；Drug Design, Research and Development编委；

Biomedcine & Pharmacotherapy特约审稿人；上海生物工程学会、中国生物技术药物学会会员。

荣誉奖励：2007年获上海市优秀青年骨干教师资助；

2016年上海科技发明奖（生物医药）三等奖（排名第1）；

2015年第28届上海市优秀科技发明选拔赛（银奖）（排名第1）；

2015年第28届上海市优秀科技发明选拔赛（铜奖）(排名第3)；

2016年校级优秀教育教学成果奖二等奖(排名第5)。

近年承担的主要科研项目：

1.Chen XX, Li YY, Chang XJ, Xie XL, Liang YT, Wang KJ, Zheng WY*, Liu HP*. A CqFerritin protein inhibits white spot syndrome virus infection via regulating iron ions in red claw crayfish Cherax quadricarinatus. Dev Comp Immunol. 2018 Jan 16;82:104-112.

2.Fabiao Hu, Daxia Pan, Wenyun Zheng*, Xiujuan He, Fuzheng Ren, Yiming Lu, Xingyuan Ma. Elucidating respective functions of two domains BIR and C-helix of human IAP survivin for precise targeted regulating mitotic cycleapoptosis and autophagy of cancer cells. Oncotarget. 2017,8(69)：113687-113700 

3. Di Liu, Fabiao Hu, Wenpeng Wang, Dong Wu, Xiujuan He, Wenyun Zheng*, Haipeng Liu*, Xingyuan Ma* Elucidating bottlenecks of the efficient preparation of an AB5-hexamer mucosal adjuvant protein LTm by genetic engineering. Journal of Microbiology and Biotechnology. 2017, 27(8), 1461-147.

4.Xingyuan Ma, Yi Zhang, Yanyan Kang, Linfeng Li,Wenyun Zheng*. A recombinant protein TmSm(T34A) can inhibit proliferation and proapoptosis to breast cancer stem cells(BCSCs) by down-regulating the expression of Cyclin D1.Biomed Pharmacother. 2016, 23(84):373-381

5.Xingyuan Ma, Nanjing Lin, Yanyan Kang, Linfeng Li,Wenyun Zheng*, Screening and identification of highly specific McAbs for discovering novel biomarkers of bone marrow stromal cells,Monoclonal Antibody in immunodiagnosis and immunotherapy,2016, 35(4): 199-211.

6.Liqun Wang, Yanyan Kang,Wenyun Zheng *, LinfengLi, Lei Shi, Xingyuan Ma. Effect on apoptosis and cell cycle of recombinant double negative dominant mutation Survivin (T34/117A) in breast cancer cell B-Cap-37.Biomedicine & Pharmacotherapy, 2014, 68(3): 277–284

7.Nanjing Lin#,Wenyun Zheng#, Linfeng Li ,Hui Liu, Tianwen Wang, Ping Wang, Xingyuan Ma,. A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells. Targeted Oncology. 2014, 9(2): 163-170(coauthor)

8.Wenyun Zheng, Wenyao Zhang, Wei Hu, and Yi Yang，Exploring the Smallest Active Fragment of HsQSOX1b and Discovery of a Highly Efficient Oxidative Engine, PLOS ONE. 2012,7 (7): e40935. doi:10.1371

9.Yuxin Xu#,Wenyun Zheng#，Tianwen Wang, Ping Wang, Ling Zhu, Xingyuan Ma*., Genetic protein TmSm(T34A) enhances sensitivity of chemotherapy to breast cancer cell lines as a synergistic drug to doxorubicin. Biomedicine & Pharmacotherapy, 2012, 66(5): 368-372 (#Coauthor)

10.Wenyun Zheng,Yanyan Chu, Qin Yin, Charles Yang, Wenyao Zhang, Yun Tang, Yi Yang. Crucial effect of the First CXXC Motif of Human QSOX 1b on the Activity to different substrates. Journal of Biochemistry. 2011, 149(3):293-300

11.Wenyun Zheng, Yanyan Kang, Linfeng Li, Yuxin Xu, Xingyuan Ma, Levels of effectiveness of gene therapies targeting survivin and its splice variants in human breast cancer cells.Drug Discoveries & Therapeutics. 2011, 5(6):293-2989.

12.Na Zhang, Hua Guo,Wenyun Zheng, Tianwen Wang, Ping Wang, Xingyuan Ma*. Design and screening of a chimeric survivin-specific nanobody and its anticancer activities in vitro. Anti-Cancer Drugs. 2016，27(9):839-47.

13.Na Zhang, Hua Guo,Wenyun Zheng, Ping Wang, Xingyuan Ma*.The small and powerful nanobodies (Nbs) originating from peculiar animals used for therapy of cancers.International Journal of Cancer Studies & Research. 2016, 4: 1-7.

14.Di Liu, Hua Guo,Wenyun Zheng, Na Zhang, Tianwen Wang, Ping Wang, Xingyuan Ma*.Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin.Applied Microbiology and Biotechnology, 2016, 100(11):1-10 

15.Di Liu, Na Zhang,Wenyun Zheng, Hua Guo, Xiaoli Wang, Tianwen Wang, Ping Wang, Xingyuan Ma*.A novel method for efficient preparation of mucosal adjuvant Escherichia coli Heat-Labile enterotoxin mutant (LTm) by artificially assisted self-assembly in vitro. Applied Biochemistry and Biotechnology. 2016, (2):1-13

16.Shunxiang Xia, Xueyan Zhao , Benjamin Frigo-Vaz, Wenyun Zheng, Jungbae Kim , Ping Wang，Cascade enzymatic reactions for efficient carbon sequestration,Bioresource Technology, 2015,182:368–372

17.Guoying Dai,Wenyun Zheng, Xingyuan Ma, Ping Wang. Multisite mutation of monomer surviving with enhanced effect on   apoptosis regulation of breast cancer cells.Biomedicine & Pharmacotherapy, 2015, 69(6): 111-118 

18.Wenyao Zhang,Wenyun Zheng, Miaowei Mao, Yi Yang. Highly Efficient Folding of Multi-Disulfide Proteins in Superoxidizing Escherichia coli Cytoplasm.Biotechnology and Bioengineering, 2014,9(6)138-245

19.Hailong Chen,Xingyuan Ma, Zhi Li, Qiaoyun Shi,Wenyun Zheng, Yang Liu, Ping Wang. Functionalization of single-walled carbon nanotubes enables efficient intracellular delivery of siRNA targeting MDM2 to inhibit breast cancer cells growth.Biomedicine & Pharmacotherapy, 2012, 66 (5) :334-338.

20.Xingyuan Ma, Bi Yao,Wenyun Zheng, Linfeng Li*. Comparative study on characterization of recombinant B subunit of E. coli heat-labile enterotoxin (rLTB) prepared from E. coli and P. patoris. J. Microbiol. Biotechnol. 2010, 20(3):550-557. 

21. Yanyan Chu, Charles Yang, Xianjun Chen, Wenyun Zheng, Yi Yang, Yun Tang，Structure–function analysis of human protein Ero1-La,Biochemical and Biophysical Research Communications, 2009, 389:645–650.  

22. Haiyi Zhang, Yu Zheng, QinghaiLiu, Xinyi Tao,Wenyun Zheng, Xingyuan Ma*, Dongzhi Wei*. Development of a fed-batch process for the production of anticancerdrug TATm-survivin(T34A) in Escherichia coli. Biochemical Engineering Journal.2009, 43(2):163–168. 

23.Xingyuan Ma,Wenyun Zheng, Haiyi Zhang，Xinyi Tao，Dongzhi Wei*. Large scale preparation and characterization of a genetically engineering protein and biological activity of suppressing proliferation and rapid pro-apoptosis to carcinoma cells.Journal of Biotechnology.2008, S75-S98

24.Xingyuan Ma, Zheng Wenyun, Tianwen Wang. Leukocyte function-associated antigen-1 structure, function and application prospects.Protein and Peptide Letters, 2006, 13: 397-400.

25.Zheng Wenyun, Ma Xingyuan, Wei Dongzhi, Ma Yushu, Wang Tianwen, Wang Jinzhia, Liu Qinghai, Yang Shengli. Preparation of recombinant HIV-TATm-survivin (T34A) protein and its pro-apoptosis activity to four cancer cell lines in Vitro,Chinese Journal of Biotechnology, 2006.22(2): 285-92

26.Wenyun Zheng, Xingyuan Ma, Dongzhi Wei, Tianwen Wang, Yushu Ma, Shengli Yang. Molecular Cloning and Bioinformatics Analysis of a Novel Spliced Variant of Survivin from Human Breast Cancer Cells,DNA Sequence, 2005, 16 (5): 321–328.