黄瑾



黄瑾   博士、教授、博士生导师

 

电话：021-64253681

地址：梅陇路130号实验18楼627室

Email：huangjin@ecust.edu.cn

 

个人简介：

  

上海市浦江人才计划获得者。先后荣获华东理工大学优秀青年女教师（2012）；华东理工大学研究生优秀指导教师（2013、2014、2015）；上海市研究生优秀成果（学位论文）（指导教师：2013）。作为项目负责人，已完成和正在承担共计10余项国家和省部课题，包括来自国家自然科学委、教育部、上海市科委和上海市教委等研究计划。迄今已在Angew. Chem. Int. Ed.、Haematologica、Oncogene、J. Med. Chem.等国内外重要期刊发表学术论文90余篇，现为Med. Res. Rev.、J. Med. Chem.、ACS Med. Chem. Lett.等药学知名期刊的审稿人。


 

主要研究方向：

1）肿瘤治疗新药物发现及体内外活性评价

2）免疫性疾病治疗新药物筛选及药理活性评价

3）药物作用新机制挖掘

4）药物筛选新方法开发

5）关键药物靶标的结构生物学研究


课题组发表论文列表（*为通讯作者）：


2018年

  1. Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng*, Weiqiang Lu*, Jin Huang*. Pharmacologic inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.Haematologica. 2018 Jun 7. pii: haematol.2018.188185.

  2. Yaqian Wang, Chan Cao, Yilun Ying , Shuang Li, Mingbo Wang, Jin Huang,  Yitao Long*. Rationally Designed Sensing Selectivity and Sensitivity of an Aerolysin Nanopore via Site-Directed Mutagenesis.ACS Sens (ACS Sensors). 2018 Apr 27; 3(4): 779-783.

  3. Yaqian Wang, Mengyin Li, Hu Qiu, Chan Cao, Mingbo Wang, Xueyuan Wu, Jin Huang, Yilun Ying*, Yitao Long*. Identification of Essential Sensitive Regions of the Aerolysin Nanopore for Single Oligonucleotide Analysis.Anal Chem (Analytical Chemistry). 2018 Jul 3; 90(13): 7790-7794.

  4. Dang Wu, Lepeng Wang, Yanhong Yang, Jin Huang, Yuhua Hu, Yongwei Shu, Jingyu Zhang, Jing Zheng*. MAD2-p31comet axis deficiency reduces cell proliferation, migration and sensitivity of microtubule-interfering agents in glioma. Biochem Biophys Res Commun (Biochemical and Biophysical Research Communications). 2018 Mar 25; 498(1): 157-163

  5. Zengrui Wu, Weiqiang Lu, Weiwei Yu, Tianduanyi Wang, Weihua Li, Guixia Liu, Hankun Zhang, Xiufeng Pang, Jin Huang, Mingyao Liu*, Feixiong Cheng*, Yun Tang*. Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches. Pharmacol Res (Pharmacological Research). 2018 Mar; 129: 400-413.

  6. GuiXiang Yang, SongLan Ge, Yan Wu, Jin Huang, ShiLiang Li*, Rui Wang*, Lei Ma*. Design, synthesis and biological evaluation of 3-piperazinecarboxylate sarsasapogenin derivatives as potential multifunctional anti-Alzheimer agents. Eur J Med Chem (European Journal of Medicinal Chemistry). 2018 May 1; 156: 206-215.

2017年

  1. 1. Weiqiang Lu, Feixiong Cheng, Wenzhong Yan, Xi Li, Xue Yao, Wenqiang Song, Mingyao Liu, Xu Shen, Hualiang Jiang, Jing Chen, Jian Li*, Jin Huang*. Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017 Aug 17;36(33):4719-4731

    2. Weiqiang Lu, Xue Yao, Ping Ouyang, Ningning Dong, Dang Wu, Xingwu Jiang, Zengrui Wu, Chen Zhang, Zhongyu Xu, Yun Tang, Shien Zou, Mingyao Liu, Jian Li, Minghua Zeng, Ping Lin, Feixiong Cheng*, Jin Huang*. Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. J Med Chem (Journal of Medicinal Chemistry). 2017 Mar 9; 60(5): 1817-1828. 

    3. Jingyuan Wang, Xue Yao, Jin Huang*. New Tricks for Human Farnesyltransferase Inhibitor: Cancer and Beyond. MedChemCommun, 2017;8(5): 841-854. (邀稿综述)

    4. Wenhua Chen, Zhenghui Huang, Wanyan Wang, Fei Mao,Longfei Guan, Yun Tang, Hualiang Jiang, Jian Li, Jin Huang*, Lubin Jiang*, Jin Zhu*. Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely. Bioorg Med Chem (Bioorganic & Medicinal Chemistry). 2017 Dec 15; 25(24): 6467-6478

  

2016年

1. Zengrui Wu, Weiqiang Lu, Dang Wu, Anqi Luo, Hanping Bian, Jie Li, Weihua Li, Guixia Liu, Jin Huang*, Feixiong Cheng*, Yun Tang*.In silico prediction of chemical mechanism-of-action via an improved network-based inference method. Br J Pharmacol (British Journal of Pharmacology). 2016 Sep 20;173:3372-3385.

2. Li Lang, Ningning Dong, Deyan Wu, Xue Yao, Weiqiang Lu*, Chen Zhang, Ping Ouyang, Jin Zhu, Yun Tang, Wei Wang, Jian Li*,Jin Huang*.2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors. J Enzyme Inhib Med Chem (Journal of Enzyme Inhibition and Medicinal Chemistry). 2016 Sep 2; 31(sup4):98-105.

3. Minghua Zeng*, Zheng Yin, Zehui Liu, Haibing Xu, Yingchun Feng, Yueqiao Hu, Lixian Chang, Yuexing Zhang, Jin Huang*, Mohamedally Kurmoo. Assembly of a Highly Stable Luminescent Zn5 Cluster and Application to Bio-Imaging. Angew Chem Int Ed Engl (Angewandte Chemie International Edition). 2016 Sep 12; 55(38): 11407-11411.

4. Xue Yao, Dang Wu, Ningning Dong, Ping Ouyang, Jiaqian Pu, Qian Hu, Jingyuan Wang, Weiqiang Lu*,Jin Huang*. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci (International Journal of Molecular Sciences). 2016 Jul 25; 17(8). pii: E1199.

5. Huiling Pan, Qian Hu, Jingyuan Wang, Zehui Liu, Dang Wu, Weiqiang Lu*, Jin Huang*. Myricetin is a novel inhibitor of human inosine 5'-monophosphate dehydrogenase with anti-leukemia activity. Biochem Biophys Res Commun (Biochemical and Biophysical Research Communications). 2016 Sep 2; 477(4): 915-922.

6. Jiling Li, Dang Wu, Xiaoyong Xu, Jin Huang, Xusheng Shao*, Zhong Li*. Design, synthesis and inhibitory activity against human dihydroorotate dehydrogenase (hDHODH) of 1,3-benzoazole derivatives bearing amide units. Bioorg Med Chem Lett (Bioorganic & Medicinal Chemistry Letters). 2016 Jul 1; 26(13): 3064-3066.

7.Tianshu Zhang, Wei Wang, Jin Huang, Xia Liu*, Haiyan Zhang*, Naixia Zhang*. Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia. BMC Neurosci (BMC Neuroscience). 2016 May 20; 17(1): 25.

8. Qiang Xiao, Ningning Dong, Xue Yao, Dang Wu, Yanli Lu, Fei Mao, Jin Zhu, Jian Li, Jin Huang, Aifang Chen, Lu Huang, Xuehai Wang, Guangxiao Yang, Guangyuan He*, Yong Xu*, Weiqiang Lu*. Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H. Sci Rep (Scientific Reports). 2016 Apr 29; 6: 25298.

9. Wei Zhou, Shiliang Li, Weiqiang Lu, Jun Yuan, Yufang Xu, Honglin Li*,Jin Huang*, Zhenjiang Zhao*. Isoindole-1,3-dione derivatives as RSK2 inhibitors: synthesis, molecular docking simulation and SAR analysis. MedChemCommun. 2016, 7: 292-296.
网页发布时间: 2019-06-18