何薇薇

何薇薇，博士

副教授,博导

电话：021-64252293

地址：上海市徐汇区梅陇路130号实验十八楼1219室；邮编：200237

个人简历：

2007年6月毕业于中国科学技术大学，获硕士学位，从事生物化学及结构生物学研究；随后赴美，2013年2月毕业于美国Scripps研究所，获博士学位，从事神经肌肉萎缩症的分子生物学机制研究。2014年7月加入华东理工大学药学院，任副教授。2015年入选上海市浦江人才计划。作为项目负责人，目前主持国家自然科学基金（青年，面上），教育部基本科研业务费探索基金，并参与科技部“973计划”（青年项目）。

研究方向：天然产物的化学生物学，信号通路（NF-κB，Hippo，PI3K-AKT...），泛素化、类泛素化修饰，癌症与炎症

代表性论文：

1. Gongcai Lan, Jie Zhang, Wenbo Ye, Fan Yang, Ang Li*, Weiwei He*& Wei-Dong Zhang* Celastrol as a tool for the study of the biological events of metabolic diseases. SCIENCE CHINA Chemistry, 2019, 62(4), 409–416.

2. Zhongyin Zhang, Jinxin Wang, Jian Li, Fan Yang, Guodu Liu, Wenjun Tang, Weiwei He, Jian-Jun Fu, Yun-Heng Shen*, Ang Li*, and Wei-Dong Zhang* Total Synthesis and Stereochemical Assignment of Delavatine A: Rh-Catalyzed Asymmetric Hydrogenation of Indene-Type Tetrasubstituted Olefins and Kinetic Resolution through Pd-Catalyzed Triflamide-Directed C–H Olefination. J. Am. Chem. Soc. 2017, 139 (15), 5558–5567.

3. Jinpeng Pei, Shupeng Zhou, Fan Yang, Yu Sun, Ang Li*, Wei-Dong Zhang*, and Weiwei He*, Identification and mechanistic studies of a cell cycle regulator JP18 from a library of synthetic indole terpenoid mimics. Chem. Asian J. 2016, 11, 2715–2718.

4. Zhongyin Zhang, Fan Yang, Jian-Jun Fu, Yun-Heng Shen*, Weiwei He* and Wei-Dong Zhang*, Delavatine A, a structurally unusual cyclopenta[de] isoquinoline alkaloid from Incarvillea delavayi, RSC advances, 2016, 6, 65885–65888.

5. Litao Sun, Ana Cristina Gomes, Weiwei He, Huihao Zhou, Xiaoyun Wang, David W. Pan, Paul Schimmel, Tao Pan*, and Xiang-lei Yang*,Evolutionary gain of alanine mischarging to non-cognate tRNAs with a G4:U69 base pair. J Am Chem Soc. 2016, 138(39), 12948–12955.

6. Weiwei He§, Ge Bai§, Huihao Zhou, Na Wei, Nicholas M. White, Janelle Lauer, Huaqing Liu, Yi Shi, Calin Dan Dumitru, Karen Lettieri, Veronica Shubayev, Albena Jordanova, Velina Guergueltcheva, Patrick Griffin, Robert W. Burgess, Samuel L. Pfaff* and Xiang-Lei Yang* (§these authors contribute equally), CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature, 2015, 526(7575), 710–714.

7. Rongcai Yue, Xia Li, Bingyang Chen, Jing Zhao, Weiwei He, Hu Yuan, Xing Yuan, Na Gao, Guozhen Wu, Huizi Jin, Lei Shan*, Weidong Zhang*, Astragaloside IV attenuates glutamate-induced neurotoxicity in PC12 cells through Raf-MEK-ERK pathway. PLOS ONE, 2015, 10(5):e0126603.

8. Xinhui Tian, Li Li, Xin Fang, Jianping Zhang, Jinpeng Pei, Weiwei He, Lei Shan, Yunheng Shen and Weidong Zhang, (−)- and (+)-Merrilliaquinone, a pair of new quinone enantiomers from Illicium merrillianum and their distinctive cytotoxic effect on human hepatoma cells. RSC Advances, 2015, 5, 75857–75862.

9. Min Chul Park, Taehee Kang, Da Jin, Jung Min Han, Sang Bum Kim, Yun Jung Park, Kiwon Cho, Young Woo Park, Min Guo, Weiwei He, Xiang-Lei Yang, Paul Schimmel, and Sunghoon Kim*, Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. PNAS Plus 2012, doi/10.1073/pnas.1200194109.

10. Weiwei He§, Hui-Min Zhang§, Yeeting E. Chong, Min Guo, Alan G. Marshall, and Xiang-Lei Yang*(§these authors contribute equally), Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening. Proc. Natl. Acad. Sci. USA, 2011, 108, 12307–12312.